抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.

The Halogen Bond

Owing to their outstanding structural, chemical, and functional diversity, metal-organic frameworks (MOFs) have attracted considerable attention over the last two decades in a variety of energy-related applications. Notably missing among these, until recently, were applications that required good charge transport coexisting with porosity and high surface area. Although most MOFs are electrical insulators, several materials in this class have recently demonstrated excellent electrical conductivity and high charge mobility. Herein we review the synthetic and electronic design strategies that have been employed thus far for producing frameworks with permanent porosity and long-range charge transport properties. In addition, key experiments that have been employed to demonstrate electrical transport, as well as selected applications for this subclass of MOFs, will be discussed.

Electrically Conductive Porous Metal–Organic Frameworks

Metal-organic frameworks (MOFs), also known as coordination polymers, represent an interesting type of solid crystalline materials that can be straightforwardly self-assembled through the coordination of metal ions/clusters with organic linkers. Owing to the modular nature and mild conditions of MOF synthesis, the porosities of MOF materials can be systematically tuned by judicious selection of molecular building blocks, and a variety of functional sites/groups can be introduced into metal ions/clusters, organic linkers, or pore spaces through pre-designing or post-synthetic approaches. These unique advantages enable MOFs to be used as a highly versatile and tunable platform for exploring multifunctional MOF materials. Here, the bright potential of MOF materials as emerging multifunctional materials is highlighted in some of the most important applications for gas storage and separation, optical, electric and magnetic materials, chemical sensing, catalysis, and biomedicine.

Emerging Multifunctional Metal-Organic Framework Materials.

The present invention relates to novel organic electroluminescent compounds exhibiting high luminous efficiency, and organic electroluminescent devices comprising the same. The organic electroluminescent compounds according to the invention are represented by Chemical Formula (1):

Novel organic electroluminescent compounds and organic electroluminescent device using the same

Solid-State Room-Temperature Near-Infrared Photoluminescence of a Stable Organic Radical

Chemical reduction of Li+@C60 by decamethylferrocene to produce neutral Li+@C60•–

Synthesis, structure and magnetic behavior of new 1D metal–organic coordination polymer with Fe3O core

We previously reported protonation-induced double cyclization reaction of 1,4-Ar2Aq and 1,5-Ar2Aq (Ar2Aq: bis(arylethynyl)anthraquinone) with strong acid HX that generated the corresponding dipyryl...

Protonation-induced cyclization of 1,8-bis(arylethynyl)anthraquinones: Monopyrylium salt formation and intensification of donor-acceptor interaction

A novel molecular heterospin system composed of high-spin MnII (S = 5/2) and (3,5-dichloro-4-pyridyl)bis(2,4,6-trichlorophenyl)methyl radical (PyBTM; S = 1/2) was developed. The MnII ion formed distorted octahedral coordination geometry with two PyBTM radicals coordinated in the trans configuration. Magnetic studies disclosed an intramolecular antiferromagnetic exchange interaction between the spins on PyBTM and MnII with JR–Mn/kB of −9.7 K. The antiferromagnetic interaction was confirmed by broken-symmetry density functional theory calculations. This study reveals the definite intramolecular exchange interaction in the MnII–triarylmethyl radical system for the first time.

Tetsuro Kusamoto

Papers

Solid-State Room-Temperature Near-Infrared Photoluminescence of a Stable Organic Radical

Chemical reduction of Li+@C60 by decamethylferrocene to produce neutral Li+@C60•–

Synthesis, structure and magnetic behavior of new 1D metal–organic coordination polymer with Fe3O core

Protonation-induced cyclization of 1,8-bis(arylethynyl)anthraquinones: Monopyrylium salt formation and intensification of donor-acceptor interaction

Structural and magnetic investigations of a heterospin system composed of high-spin Mn(II) and pyridyl-containing triarylmethyl radicals