T
Tewis Bouwmeester
Researcher at Novartis
Publications - 100
Citations - 21203
Tewis Bouwmeester is an academic researcher from Novartis. The author has contributed to research in topics: Wnt signaling pathway & Gastrulation. The author has an hindex of 44, co-authored 99 publications receiving 19729 citations. Previous affiliations of Tewis Bouwmeester include European Bioinformatics Institute & Harvard University.
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Journal ArticleDOI
Human protein–protein interaction networks and the value for drug discovery
TL;DR: The 'therapeutic potential' of the 1st generation sub-genome-scale human interaction networks and disease-associated protein networks generated by yeast two-hybrid screens and affinity purification-mass spectrometry approaches are reviewed.
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AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration.
Tianliang Sun,Monika Pikiolek,Vanessa Orsini,Sebastian Bergling,Sjoerd J B Holwerda,Lapo Morelli,Philipp S. Hoppe,Lara Planas-Paz,Yi Yang,Heinz Ruffner,Tewis Bouwmeester,Felix Lohmann,Luigi Terracciano,Guglielmo Roma,Feng Cong,Jan S. Tchorz +15 more
TL;DR: Findings show hepatocytes throughout the liver can upregulate AXIN2 and LGR5 after injury and contribute to liver regeneration on demand, without zonal dominance by a putative pericentral stem cell population.
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Biochemical characterization of USP7 reveals post‐translational modification sites and structural requirements for substrate processing and subcellular localization
Amaury Ernesto Fernandez-Montalvan,Tewis Bouwmeester,Gerard Joberty,Robert Mader,Marion Mahnke,Benoit Pierrat,Jean-Marc Schlaeppi,Susanne Worpenberg,Bernd Gerhartz +8 more
TL;DR: Limited proteolysis experiments revealed that USP7 variants containing the C‐terminal domain interact more tightly with ubiquitin, suggesting that Besides playing an important role in substrate recognition and processing, this region might be involved in enzyme dimerization.
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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)
Aurelio Bonavia,Michael Franti,Erin P. Keaney,Kelli Kuhen,Mohindra Seepersaud,Branko Radetich,Jian Shao,Ayako Honda,Janetta Dewhurst,Kara Balabanis,James Monroe,Karen Wolff,Colin P. Osborne,Leanne Lanieri,Keith Hoffmaster,Jakal Amin,Judit Markovits,Michelle Broome,Elizabeth Skuba,Ivan Cornella-Taracido,Gerard Joberty,Tewis Bouwmeester,Lawrence G. Hamann,John A. Tallarico,Tommasi Ruben A,Teresa Compton,Bushell Simon +26 more
TL;DR: A discovery program that includes screen, target identification, validation, and druggability that can be broadly applied to identify and interrogate other host factors for antiviral effect starting from chemical matter of unknown target/mechanism of action is presented.
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Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.
Bernd Kinzel,Monika Pikiolek,Vanessa Orsini,Joëlle Sprunger,Andrea Isken,Svenja Zietzling,Magali Desplanches,Valerie Dubost,Daniel Breustedt,Reginald Valdez,Dong Liu,Diethilde Theil,Matthias Müller,Bill Dietrich,Tewis Bouwmeester,Heinz Ruffner,Jan S. Tchorz +16 more
TL;DR: The findings clearly establish the importance of Lgr4 and Lgr5 during embryonic gut, skin and kidney development, with a dominant role of L gr4, and supports complementary functions of both receptors.