Thamarapu Srikrishnan

TL;DR: This approach could be used as a powerful alternative to conventional protein A/G methods for the commercial preparation of non immunogen active Fab'2 fragments and could be easily recovered under mild conditions (pH 7) in the non-retained fraction.

TL;DR: It was observed that, when the same gram molecular weight of Abeta is dissolved into varying amounts of base then placed into a constant volume of aqueous buffer, a non-linear fluorescent response is obtained and this anomalous result can be alleviated and a linear dose response curve is obtained at much lower Abeta concentrations than is typically observed.

TL;DR: It is reported that CLN prevents the aggregation of beta-amyloid peptide Abeta (1-40) in vitro and that the neuroprotective effects exerted by CLN are related to the reduction of Beta-AMyloid fibrils.

TL;DR: The strategy of building branched mucin core 2 structures by three glycosidation sequence coupling three classes of glycosyl donors with the reactivity-matching acceptors proved to be successful in syntheses of modified mucin-type core structures of O-glycan.

TL;DR: In this article, two sulfated pentasaccharides, β-d-Gal6SO 3 Na-(1→3)-[β-d -Gal-(1/4)-α- l -Fuc-(1)/3)-β- d -GlcNAc-( 1/6)]-α- d-GalNAc→OMe, were synthesized using Lewis X trisaccharide 12 and 16 as donors.