Theodore J. Kaplan

TL;DR: Analyzing mouse monocyte subsets in apoE-deficient mice and tracing their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques suggests antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their C CR2-dependent responses to inflammation overall.

TL;DR: An unbiased single cell RNA-sequencing analysis of a bleomycin-induced pulmonary fibrosis model is used to characterize molecular responses to fibrotic injury and finds that activated fibroblasts are not uniquely defined but exhibit a similar, yet amplified, gene expression pattern to control cells.

TL;DR: It is shown that two of the methods employed in optimal conditions-administration of fluorescent OVA or latex particles-have broadly relevant utility in studies of pulmonary DC migration, both in the presence and absence of inflammatory mediators.

TL;DR: These results represent the first demonstration of sustained systemic release of a transgene product using HSV vectors, raising the prospect of new applications for HSV-1 vectors in the treatment of systemic disease.

TL;DR: Histology based finite element analysis is used to evaluate peak circumferential stresses in aortic and BCA lesions from six 42–56 week-old fat-fed ApoE KO mice and predicts biomechanical stress patterns in mouse BCA close to human vulnerable plaques without microcalcification in the cap, while aorti lesions show stress tendency similar to stable lesions in human.