T
Theodore L. Munsat
Researcher at Tufts University
Publications - 28
Citations - 3642
Theodore L. Munsat is an academic researcher from Tufts University. The author has contributed to research in topics: Thyrotropin-releasing hormone & Amyotrophic lateral sclerosis. The author has an hindex of 19, co-authored 28 publications receiving 3393 citations. Previous affiliations of Theodore L. Munsat include Tufts Medical Center.
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Journal ArticleDOI
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Thomas J. Kwiatkowski,D. A. Bosco,D. A. Bosco,A. L. LeClerc,A. L. LeClerc,Eric Tamrazian,Charles R. Vanderburg,Carsten Russ,Carsten Russ,A. Davis,James M. Gilchrist,E. J. Kasarskis,Theodore L. Munsat,Paul N. Valdmanis,Guy A. Rouleau,Betsy A. Hosler,Pietro Cortelli,P. J. De Jong,Yuko Yoshinaga,Jonathan L. Haines,Margaret A. Pericak-Vance,Jianhua Yan,Nicola Ticozzi,Nicola Ticozzi,Nicola Ticozzi,Teepu Siddique,Diane McKenna-Yasek,Peter C. Sapp,Peter C. Sapp,H R Horvitz,John Landers,John Landers,Robert H. Brown,Robert H. Brown +33 more
TL;DR: Neuronal cytoplasmic protein aggregation and defective RNA metabolism thus appear to be common pathogenic mechanisms involved in ALS and possibly in other neurodegenerative disorders.
Journal ArticleDOI
The spectrum of neurologic disease associated with anti‐GM1 antibodies
Saud Sadiq,Florian P. Thomas,K. Kilidireas,S. Protopsaltis,Arthur P. Hays,K. W. Lee,S. N. Romas,N. Kumar,L. H. Den Van Berg,Maria Santoro,Dale J. Lange,David S. Younger,Robert E. Lovelace,Werner Trojaborg,William H. Sherman,James R. Miller,J. Minuk,M. A. Fehr,Robert I. Roelofs,Dave Hollander,Fenwick T. Nichols,Hiroshi Mitsumoto,J. J. Kelley,Thomas R. Swift,Theodore L. Munsat,Norman Latov +25 more
TL;DR: Patients with motor or sensorimotor peripheral neuropathy or lower motor neuron disease should be tested for anti-GM1 antibodies or anti-Gal(β1-3)GalNAc antibodies, as therapeutic reduction in antibody concentrations was reported to result in clinical improvement in some patients.
Journal ArticleDOI
Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis
Masashi Aoki,Chien Liang G. Lin,Jeffrey D. Rothstein,Brian A. Geller,Brian A. Geller,Betsy A. Hosler,Theodore L. Munsat,H. Robert Horvitz,Robert H. Brown +8 more
TL;DR: These studies indicate that germline mutations in the EAAT2 gene are infrequent and do not explain the presence of variant mRNA transcripts ofEAAT2 in more than one‐half of ALS cases.
Journal ArticleDOI
The ALS patient care database: Goals, design, and early results
Robert G. Miller,Frederick A. Anderson,Walter G. Bradley,Benjamin Rix Brooks,Hiroshi Mitsumoto,Theodore L. Munsat,Steven P. Ringel +6 more
TL;DR: The ALS Patient Care Database appears to provide valuable data on physician practices and patient-focused outcomes in ALS.
Journal ArticleDOI
A multicenter, randomized, double-blinded trial of pyridostigmine in postpolio syndrome
Daria A. Trojan,J. P. Collet,Stan Shapiro,Burk Jubelt,Robert G. Miller,James C. Agre,Theodore L. Munsat,Dave Hollander,Rup Tandan,C. Granger,A Robinson,Lois Finch,Thierry Ducruet,Neil R. Cashman +13 more
TL;DR: This study showed no significant differences between pyridostigmine and placebo-treated PPS patients on measures of quality of life, isometric strength, fatigue, and IGF-I serum levels at 6 months.