J
Jae Eun Choi
Researcher at University of Michigan
Publications - 28
Citations - 2426
Jae Eun Choi is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 9, co-authored 21 publications receiving 887 citations. Previous affiliations of Jae Eun Choi include University of California, San Francisco & University of California, San Diego.
Papers
More filters
Journal ArticleDOI
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Weimin Wang,Michael D. Green,Jae Eun Choi,Miguel Gijón,Paul D. Kennedy,Jeffrey K. Johnson,Peng Liao,Xueting Lang,Ilona Kryczek,Amanda Sell,Houjun Xia,Jiajia Zhou,Gaopeng Li,Jing Li,Wei Li,Shuang Wei,Linda Vatan,Hongjuan Zhang,Wojciech Szeliga,Wei Gu,Rebecca Liu,Theodore S. Lawrence,Candice Lamb,Yuri Tanno,Marcin Cieslik,Everett Stone,George Georgiou,Timothy A. Chan,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Weiping Zou +30 more
TL;DR: Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.
Journal ArticleDOI
Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11
Xueting Lang,Michael D. Green,Weimin Wang,Jiali Yu,Jae Eun Choi,Long Jiang,Peng Liao,Jiajia Zhou,Qiang Zhang,Ania Dow,Anjali L. Saripalli,Ilona Kryczek,Shuang Wei,Wojciech Szeliga,Linda Vatan,Everett Stone,George Georgiou,Marcin Cieslik,Marcin Cieslik,Daniel R. Wahl,Meredith A. Morgan,Arul M. Chinnaiyan,Theodore S. Lawrence,Weiping Zou +23 more
TL;DR: It is demonstrated that radiotherapy induces tumor cell ferroptosis, an unappreciated mechanism and focus for the development of effective combinatorial cancer therapy.
Journal ArticleDOI
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Jiali Yu,Michael D. Green,Michael D. Green,Shasha Li,Yilun Sun,Sara Journey,Jae Eun Choi,Syed Monem Rizvi,Angel Qin,Jessica Waninger,Xueting Lang,Zoey Chopra,Issam El Naqa,Jiajia Zhou,Yingjie Bian,Long Jiang,Alangoya Tezel,Jeremy Skvarce,Rohan K. Achar,Merna Sitto,B.S. Rosen,Fengyun Su,Sathiya Pandi Narayanan,Xuhong Cao,Shuang Wei,Wojciech Szeliga,Linda Vatan,Charles S. Mayo,Meredith A. Morgan,C.A. Schonewolf,Kyle C. Cuneo,Ilona Kryczek,Vincent T. Ma,Christopher D. Lao,Theodore S. Lawrence,Nithya Ramnath,Nithya Ramnath,Fei Wen,Arul M. Chinnaiyan,Marcin Cieslik,Ajjai Alva,Weiping Zou +41 more
TL;DR: In this paper, liver metastases siphon activated CD8+ T cells from systemic circulation, resulting in a systemic immune desert in preclinical models, and the combination of liver-directed radiotherapy and immunotherapy could promote systemic antitumor immunity.
Journal ArticleDOI
Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism.
Stephen Bent,Robert L. Hendren,Tara Zandi,Kiely Law,Jae Eun Choi,Felicia Widjaja,Luther G. Kalb,Jay Nestle,Paul A. Law +8 more
TL;DR: Internet-based, randomized controlled trials of therapies in children with ASD are feasible and may lead to marked reductions in the time and cost of completing trials, and a larger sample size is required to definitively determine the efficacy of omega-3 fatty acids.
Journal ArticleDOI
Perioperative neutrophil:lymphocyte ratio and postoperative NSAID use as predictors of survival after lung cancer surgery: a retrospective study
Jae Eun Choi,John Villarreal,Javier Lasala,Vijaya Gottumukkala,Reza J. Mehran,David C. Rice,Jun Yu,Lei Feng,Juan P. Cata,Juan P. Cata +9 more
TL;DR: It is demonstrated that preoperative NLR was demonstrated to be an independent predictor of RFS and OS in a subset of patients with early stage NSCLC, and ketorolac administration was not found to be aindependent predictor of survival.