Theofanis Karayannis

TL;DR: By combining an inducible genetic fate mapping strategy with electrophysiological analysis, this work systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE), and determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes.

TL;DR: It is found that interneuron subtypes are born with a characteristic temporal pattern and the characterization of interneurons from the Nkx6-2 lineage is extended through the application of electrophysiological methods.

TL;DR: These findings reveal a selective requirement for activity in shaping the cortical integration of specific neuronal subtypes, and show that the engulfment and cell motility 1 gene (Elmo1), a target of the transcription factor distal-less homeobox 1 (Dlx1), is selectively expressed in Re+ and Cr+ interneurons and is both necessary and sufficient for activity-dependent interneuron migration.

TL;DR: The mesoscale selective plane-illumination microscopy initiative is introduced, an open-hardware project for building and operating a light-sheet microscope that addresses these challenges and is compatible with any type of cleared or expanded sample.

TL;DR: It is shown that Cntnap4 is localized presynaptically and its loss leads to a reduction in the output of cortical parvalbumin (PV)-positive GABAergic (γ-aminobutyric acid producing) basket cells, which augments midbrain dopaminergic release in the nucleus accumbens.