Thibaut Dumas

TL;DR: The aim of the present study was to evaluate the potential of metabolomics to highlight key metabolites disrupted by a WWTP effluent extract exposure and then elucidate the biological effects of such exposure on Mediterranean mussels (Mytilus galloprovincialis).

TL;DR: A multifactorial experiment combined to Analysis of variance Multiblock Orthogonal Partial Least Squares (AMOPLS) was applied, to assess the metabolic response of wild marine mussels exposed to a wastewater treatment plant effluent, considering gender as an experimental factor.

TL;DR: It is highlighted that current metabolomics advances have enabled more accurate MeOA assessment, especially when combined with other omics approaches and the combination of metabolomics with other measured biological endpoints has also turned out to be an efficient way to link molecular effects to (sub)-individual adverse outcomes, thereby paving the way to the construction of adverse outcome pathways (AOPs).

TL;DR: In this article, an integrated metabolomics and proteogenomics approach, including data fusion strategy, was applied to gain more insight in molecular events and cellular processes triggered by carbamazepine exposure.

TL;DR: The metabolome of the Mediterranean mussel exposed to a 10 µg/L nominal concentration of the antidepressant venlafaxine was assessed, finding that the modulation pattern of impacted metabolites was not constant over time and it was gender-specific, as male and female mussels responded differently to VLF exposure.