T
Thomas B. Huffaker
Researcher at University of Utah
Publications - 14
Citations - 750
Thomas B. Huffaker is an academic researcher from University of Utah. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 10, co-authored 11 publications receiving 572 citations.
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Journal ArticleDOI
Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity
Thomas B. Huffaker,Ruozhen Hu,Marah C. Runtsch,Erin Bake,Xinjian Chen,Jimmy L. Zhao,June L. Round,David Baltimore,Ryan M. O'Connell +8 more
TL;DR: This work reveals critical roles for miRNAs in the reciprocal regulation of CD4(+) and CD8(+) T cell-mediated antitumor immunity and demonstrates the dominant nature of miR-155 during its promotion of immune responses.
Journal ArticleDOI
miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation
Ruozhen Hu,Dominique Kagele,Thomas B. Huffaker,Marah C. Runtsch,Margaret Alexander,Jin Liu,Erin Bake,Wei Su,Matthew A. Williams,Dinesh S. Rao,Thomas Möller,Gwenn A. Garden,June L. Round,Ryan M. O'Connell +13 more
TL;DR: This study discovers thatmiR-146a and miR-155 counterregulate Tfh cell development that drives aberrant GC reactions during chronic inflammation.
Journal ArticleDOI
MicroRNA-155 Confers Encephalogenic Potential to Th17 Cells by Promoting Effector Gene Expression
Ruozhen Hu,Thomas B. Huffaker,Dominique Kagele,Marah C. Runtsch,Erin Bake,Aadel A. Chaudhuri,June L. Round,Ryan M. O'Connell +7 more
TL;DR: A critical role for miR-155 is demonstrated in Th17 cells as they unleash autoimmune inflammation and it is found that this occurs through a signaling network involving mi R-155, Ets1, and the clinically relevant IL-23–IL-23R pathway.
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Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.
Margaret Alexander,Andrew G. Ramstead,Kaylyn M. Bauer,Soh Hyun Lee,Marah C. Runtsch,Jared Wallace,Thomas B. Huffaker,Dane K. Larsen,Tanya Tolmachova,Miguel C. Seabra,June L. Round,Diane M. Ward,Ryan M. O'Connell +12 more
TL;DR: Rab27-dependent exosome production contributes to homeostasis within the hematopoietic system and appropriate responsiveness to inflammatory stimuli, and is found to be important for a proper LPS response.
Journal ArticleDOI
Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.
Thomas B. Huffaker,Soh Hyun Lee,William W. Tang,Jared Wallace,Margaret Alexander,Marah C. Runtsch,Dane K. Larsen,Jacob Thompson,Andrew G. Ramstead,Warren P. Voth,Ruozhen Hu,June L. Round,Matthew A. Williams,Ryan M. O'Connell +13 more
TL;DR: It is found that miR-155 expression within T cells is required to limit syngeneic tumor growth and promote IFNγ production by T cells within the tumor microenvironment, and the results suggest that the augmentation of miR -155 expression could be used to improve anticancer immunotherapies.