J
Jimmy L. Zhao
Researcher at California Institute of Technology
Publications - 22
Citations - 3180
Jimmy L. Zhao is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Myeloid & Inflammation. The author has an hindex of 16, co-authored 19 publications receiving 2777 citations. Previous affiliations of Jimmy L. Zhao include NewYork–Presbyterian Hospital & Cornell University.
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Journal ArticleDOI
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Mark Boldin,Konstantin Taganov,Konstantin Taganov,Dinesh S. Rao,Dinesh S. Rao,Lili Yang,Jimmy L. Zhao,Manorama Kalwani,Yvette Garcia-Flores,Mui Luong,Asli Devrekanli,Jessica Xu,Guizhen Sun,Jia Tay,Peter S. Linsley,David Baltimore +15 more
TL;DR: Mice lacking miR-146a exhibit exaggerated inflammatory responses, autoimmunity, and increased rate of tumorigenesis.
Journal ArticleDOI
NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies
Jimmy L. Zhao,Dinesh S. Rao,Dinesh S. Rao,Mark Boldin,Konstantin D. Taganov,Ryan M. O'Connell,David Baltimore +6 more
TL;DR: Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF -κB is responsible for the myELoproliferative disease.
Journal ArticleDOI
MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
Henry S. Cheng,Nirojini Sivachandran,Andy K. S. Lau,Emilie Boudreau,Jimmy L. Zhao,David Baltimore,Paul Delgado-Olguin,Myron I. Cybulsky,Jason E. Fish +8 more
TL;DR: The discovery of an important negative feedback regulatory loop that controls pro‐inflammatory signalling in endothelial cells that may impact vascular inflammatory diseases is uncovered.
Journal ArticleDOI
miR-146a controls the resolution of T cell responses in mice
Lili Yang,Mark Boldin,Yang Yu,Claret Siyuan Liu,Chee Kwee Ea,Parameswaran Ramakrishnan,Konstantin Taganov,Jimmy L. Zhao,David Baltimore +8 more
TL;DR: By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.
Journal ArticleDOI
Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis
Jimmy L. Zhao,Chao Ma,Ryan M. O'Connell,Arnav Mehta,Race Diloreto,James R. Heath,David Baltimore +6 more
TL;DR: This study has uncovered an important property of HSPCs that enables them to convert danger signals into versatile cytokine signals for the regulation of stress hematopoiesis.