T
Thomas Baukrowitz
Researcher at University of Kiel
Publications - 63
Citations - 5169
Thomas Baukrowitz is an academic researcher from University of Kiel. The author has contributed to research in topics: Gating & Potassium channel. The author has an hindex of 35, co-authored 60 publications receiving 4846 citations. Previous affiliations of Thomas Baukrowitz include University of Jena & University of Oxford.
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Journal ArticleDOI
Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate.
C. Antz,Tanja Bauer,Hubert Kalbacher,Rainer Frank,Manuel Covarrubias,Hans Robert Kalbitzer,J. P. Ruppersberg,Thomas Baukrowitz,Bernd Fakler +8 more
TL;DR: Structural changes correlate with the distinct changes in binding and unbinding kinetics underlying the reduced inactivation potency of phosphorylated IDs.
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Phospholipids as Modulators of KATP Channels: Distinct Mechanisms for Control of Sensitivity to Sulphonylureas, K+ Channel Openers, and ATP
TL;DR: The effects of phospholipids on the pharmacological properties of cardiac type K(ATP) (Kir6.2/SUR2A) channels are investigated and structural features necessary to modulate K(atP) channel properties are revealed and an artificial lipid that mimicked the effects of PIPs on K( ATP) channels is revealed.
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Molecular Basis of Inward Rectification: Polyamine Interaction Sites Located by Combined Channel and Ligand Mutagenesis
Harley T. Kurata,Harley T. Kurata,L. Revell Phillips,Thierry Rose,Gildas Loussouarn,Stefan Herlitze,Hariolf Fritzenschaft,Decha Enkvetchakul,Colin G. Nichols,Thomas Baukrowitz +9 more
TL;DR: It is found that introduced glutamates at any pore-facing residue in the inner cavity, up to and including the entrance to the selectivity filter, can confer strong rectification.
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Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel
Markus Rapedius,Shozeb Haider,Katharine F Browne,Lijun Shang,Mark S.P. Sansom,Thomas Baukrowitz,Stephen J. Tucker +6 more
TL;DR: It is demonstrated that instead of interacting with K80, the RKR arginine residues form highly conserved inter‐ and intra‐subunit interactions that are important for Kir channel gating and influence pH sensitivity indirectly.
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How highly charged anionic lipids bind and regulate ion channels.
TL;DR: The modulation of channel activity by direct interaction with membrane lipids is now an emerging theme in ion channel biology and phosphoinositides such as phosphatidylinositol 4,5-bisphosphate are known to regulate the activity of most major classes of ion channel.