T
Thomas Baukrowitz
Researcher at University of Kiel
Publications - 63
Citations - 5169
Thomas Baukrowitz is an academic researcher from University of Kiel. The author has contributed to research in topics: Gating & Potassium channel. The author has an hindex of 35, co-authored 60 publications receiving 4846 citations. Previous affiliations of Thomas Baukrowitz include University of Jena & University of Oxford.
Papers
More filters
Journal ArticleDOI
Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
Ehsan Nematian-Ardestani,M. Firdaus Abd-Wahab,Franck C. Chatelain,Han Sun,Marcus Schewe,Thomas Baukrowitz,Stephen J. Tucker +6 more
TL;DR: It is found here that only very strong nonphysiological depolarization produces voltage-dependent activation of heterologously expressed TWIK-1, and it is concluded that TWik-1 displays unique SF gating properties among the family of K2P channels.
Journal ArticleDOI
A pharmacological masterkey mechanism to unlock the selectivity filter gate in K plus channels.
Marcus Schewe,Han Sun,Alexandra Mackenzie,Ashley C. W. Pike,Friederike Schulz,Christina Constantin,Aytug K. Kiper,Linus J. Conrad,Wendy González,Bert L. de Groot,Niels Decher,Bernd Fakler,Elisabeth P. Carpenter,Stephen J. Tucker,Thomas Baukrowitz +14 more
Journal ArticleDOI
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
William Weijen Chang,Ann-Sophie Matt,Marcus Schewe,Marianne Musinszki,Sandra Grüssel,Jonas Brandenburg,David A. Garfield,Markus Bleich,Thomas Baukrowitz,Marian Y. Hu +9 more
TL;DR: Otopetrin-selective channels are critically important for the mineralization of otoliths and statoconia in vertebrates but their underlying cellular mechanisms remain largely unknown as mentioned in this paper.
Journal Article
Regulation of CFTR channel gating.
Journal ArticleDOI
State-dependent network connectivity determines gating in a K+ channel.
Murali K. Bollepalli,Philip W. Fowler,Markus Rapedius,Lijun Shang,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +6 more
TL;DR: This mutagenic perturbation analysis uncovered an extensive, state-dependent network of physically interacting residues that stabilizes the pre-open and open states of the channel, but fragments upon channel closure.