T
Thomas Baukrowitz
Researcher at University of Kiel
Publications - 63
Citations - 5169
Thomas Baukrowitz is an academic researcher from University of Kiel. The author has contributed to research in topics: Gating & Potassium channel. The author has an hindex of 35, co-authored 60 publications receiving 4846 citations. Previous affiliations of Thomas Baukrowitz include University of Jena & University of Oxford.
Papers
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Journal ArticleDOI
A non-canonical voltage sensor controls gating in K2P K+ channels.
Marcus Schewe,Ehsan Nematian-Ardestani,Han Sun,Han Sun,Marianne Musinszki,Sönke Cordeiro,Giovanna Bucci,Bert L. de Groot,Stephen J. Tucker,Markus Rapedius,Thomas Baukrowitz +10 more
TL;DR: Voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of 3-4 ions into the high electric field of an inactive selectivity filter, which provides insight into the functional plasticity of a K+-selective filter.
Journal ArticleDOI
Insights into the structural nature of the transition state in the Kir channel gating pathway
Philip W. Fowler,Murali K. Bollepalli,Markus Rapedius,Ehsan Nematian-Ardestani,Lijun Shang,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +7 more
TL;DR: The gating kinetics of different mutations within key parts of this extensive gating network suggest that the structure of the transition state (TS), which connects the pre-open and closed states of the channel, more closely resembles the structureOf thePre-open state.
Journal ArticleDOI
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation
Christina B. Schroeter,Christopher Nelke,Marcus Schewe,Lucas Spohler,Alexander M. Herrmann,Thomas Müntefering,Niklas Huntemann,Maria Kuzikov,Philip Gribbon,Sarah Albrecht,Stefanie Bock,Petra Hundehege,L. C. Neelsen,Thomas Baukrowitz,Guiscard Seebohm,Bernhard Wünsch,Stefan Bittner,Tobias Ruck,Thomas Budde,Sven G. Meuth +19 more
TL;DR: In this article , the TWIK-related potassium channel 1 (TREK1) activators were identified and validated using patch-clamp measurements of Xenopus laevis oocytes expressing TREK1.
Journal ArticleDOI
Inward rectifier potassium channels and a multitude of intracellular gating molecules
Posted ContentDOI
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide (PIP2) and fatty acid metabolism (LC-CoA)
Elena B. Riel,Bjoern C. Juers,Soenke Cordeiro,Marianne Musinszki,Marcus Schewe,Thomas Baukrowitz +5 more
TL;DR: In this article, the effects of polyanionic lipids (PIP2 and oleoyl-CoA) on the K2P channels were investigated and it was shown that PIP2-induced inhibition in TASK-1 and TALK-3 channels is mediated by closure of the recently identified lower X-gate as critical mutations within the gate (i.e. L244A, R245A).