T
Thomas Fröhlich
Researcher at Ludwig Maximilian University of Munich
Publications - 140
Citations - 5294
Thomas Fröhlich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Proteome & Medicine. The author has an hindex of 34, co-authored 120 publications receiving 4089 citations. Previous affiliations of Thomas Fröhlich include Center for Integrated Protein Science Munich.
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Journal ArticleDOI
Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis.
Maik Dahlhoff,Thomas Fröhlich,Georg J. Arnold,Udo Müller,Heinrich Leonhardt,Christos C. Zouboulis,Marlon R. Schneider +6 more
TL;DR: In this article, the authors used qRT-PCR to confirm expression of transcripts encoding the six previously unidentified proteins, ALDH1A3 and EPHX4, in SZ95 sebocytes and in another sebocyte line (SebE6E7).
Proteomic Characterization of Archaeal Ribosomes Reveals the Presence of Novel Archaeal-Specific
Viter Márquez,Thomas Fröhlich,Jean Paul Armache,Daniel Sohmen,Alexandra Dönhöfer,Aleksandra Mikolajka,Otto Berninghausen,Michael Thomm,Roland Beckmann,Georg J. Arnold,Daniel N. Wilson +10 more
TL;DR: This study reports the first comprehensive two-dimensional PAGE and mass spectrometry analysis of archaeal ribosomes isolated from the thermophilic Pyrobaculum aerophilum and the thermoacidophilic Sulfolobus acidocaldarius Crenarchaeota, and identifies three hypothetical proteins that appear to be bona fide r-proteins of the S. acidOCaldarius large subunit.
Journal ArticleDOI
Analysis of the HUPO Brain Proteome reference samples using 2-D DIGE and 2-D LC-MS/MS.
Thomas Fröhlich,Derrick Helmstetter,Monica Zobawa,Anna C. Crecelius,Thomas Arzberger,Hans A. Kretzschmar,Georg J. Arnold +6 more
TL;DR: Within the HUPO BPP brain protein database, a robust 2‐D LC‐MS/MS method was applied to murine postnatal day 7 and human post‐mortem brain samples and 350 human and 481 mouse proteins could be identified by at least two different peptides.
Journal ArticleDOI
ADNP Is a Therapeutically Inducible Repressor of WNT Signaling in Colorectal Cancer
Cristina Blaj,Agnes Bringmann,Eva Marina Schmidt,Manuela Urbischek,Sebastian Lamprecht,Thomas Fröhlich,Georg J. Arnold,Stefan Krebs,Helmut Blum,Heiko Hermeking,Heiko Hermeking,Andreas Jung,Andreas Jung,Thomas Kirchner,Thomas Kirchner,David Horst,David Horst +16 more
TL;DR: The findings indicate that ADNP is a tumor suppressor and promising prognostic marker, and that ketamine treatment with ADNP induction is a potential therapeutic approach that may add benefit to current treatment protocols for patients with colorectal cancer.
Journal ArticleDOI
Detection of wild type and deleted latent membrane protein 1 (LMP1) of Epstein-Barr virus in clinical biopsy material.
John M. Nicholls,Peter Hahn,Elisabeth Kremmer,Thomas Fröhlich,Georg J. Arnold,Jonathan S.T. Sham,Dora L.W. Kwong,Friedrich A. Grässer +7 more
TL;DR: Results demonstrate specificity of the monoclonal cocktail for detecting the non-wild type LMP1 and the ability to sub-differentiate between the mediterranean type of LMP 1 and the CAO-LMP1.