J
John M. Nicholls
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 251
Citations - 22293
John M. Nicholls is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 66, co-authored 231 publications receiving 19014 citations. Previous affiliations of John M. Nicholls include Guangzhou Medical University & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
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Unravelling the Role of O-glycans in Influenza A Virus Infection
Juliane Mayr,Kam Lau,Jimmy C. C. Lai,Ivan A. Gagarinov,Yun Shi,Sarah McAtamney,Renee W. Y. Chan,John M. Nicholls,Mark von Itzstein,Thomas Haselhorst +9 more
TL;DR: It is suggested that sialylated Galβ(1,3)GalNAc as O-glycan core 1 glycoforms are involved in the influenza A virus life cycle and play a particularly crucial role during infection of HPAI strains.
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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Yumiko Imai,Keiji Kuba,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria A. Ermolaeva,Maria A. Ermolaeva,Ruud A. W. Veldhuizen,Y.H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John M. Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger +27 more
TL;DR: It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI.
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Pathogenesis and transmission of SARS-CoV-2 in golden hamsters.
Sin Fun Sia,Li Meng Yan,Alex W.H. Chin,Kevin Fung,Ka Tim Choy,Alvina Y L Wong,Prathanporn Kaewpreedee,Ranawaka A.P.M. Perera,Leo L.M. Poon,John M. Nicholls,Malik Peiris,Hui-Ling Yen +11 more
TL;DR: The pathogenicity and transmissibility of SARS-CoV-2 in golden (Syrian) hamsters resemble features of COVID-19 in human patients, suggesting that these hamsters could be used to model this disease.
Journal ArticleDOI
Lung pathology of fatal severe acute respiratory syndrome
John M. Nicholls,Leo L.M. Poon,Kam Cheong Lee,Wai F. Ng,Sik T. Lai,Chung Y. Leung,Chung M. Chu,Pak K. Hui,K.L. Mak,Wilina Lim,Kin W. Yan,Kwok H. Chan,Ngai C. Tsang,Yi Guan,Kwok-Yung Yuen,J. S. Peiris +15 more
TL;DR: The presence of haemophagocytosis supports the contention that cytokine dysregulation may account, at least partly, for the severity of the clinical disease.