Thomas Høj Rasmussen

TL;DR: The potencies of the pesticides to react as hormone agonists or antagonists are low compared to the natural ligands, but the integrated response in the organism might be amplified by the ability of the pesticide to act via several mechanism and the frequent simultaneous exposure to several pesticides.

TL;DR: Evidence is presented that the di-ortho, multiple-chloro substituted biphenyls, PCB #138, PCB#153 and PCB#180, can compete with the binding of the natural ligand to two nuclear receptors and thus possess the ability to interfere with sexual hormone regulated processes.

TL;DR: It is suggested that PP ARδ may play a role in the proliferation of adipocyte precursor cells, whereas activation of endogenous PPARδ in 3T3-L1 cells appears to have only minor impact on the processes leading to terminal adipocyte differentiation.

TL;DR: The results indicate that TTA inhibits proliferation of glioma cancer cells through both PPARGamma-dependent and PPARgamma-independent pathways, of which the latter appears to predominate.

TL;DR: The in vitro estrogenicity response offers a promising and feasible approach for an aggregated exposure assessment for xenoestrogens in serum.