T
Thomas J. Kunicki
Researcher at Scripps Research Institute
Publications - 142
Citations - 9276
Thomas J. Kunicki is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Platelet & Platelet membrane glycoprotein. The author has an hindex of 52, co-authored 142 publications receiving 9103 citations. Previous affiliations of Thomas J. Kunicki include Marquette University & University of Washington.
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Journal ArticleDOI
Platelet surface glycoproteins. Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery.
J N George,E B Pickett,S Saucerman,Rodger P. McEver,Thomas J. Kunicki,N Kieffer,Peter J. Newman +6 more
TL;DR: Patients with adult respiratory distress syndrome and patients after cardiac surgery with cardiopulmonary bypass demonstrated changes consistent with membrane fragmentation without secretion: a decreased platelet surface concentration of GP Ib and GP IIb with no increase of GMP-140 and TSP, and an increased plasma concentration of platelet membrane microparticles.
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The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platelet glycoproteins Ic-IIa.
TL;DR: Results show that multiple ECMRs function in combination to mediate cell adhesion to complex EMC templates and predicts that variation in ECM composition and ECMR expression may direct cell localization to specific tissue domains.
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A study of variables affecting the quality of platelets stored at "room temperature".
Thomas J. Kunicki,Thomas J. Kunicki,M. Tuccelli,M. Tuccelli,G. A. Becker,G. A. Becker,Richard H. Aster,Richard H. Aster +7 more
TL;DR: Platelets from female donors tolerated storage less well than did platelets from male donors, possibly because the lower hematocrit of blood collection from females resulted in greater initial acidity of the concentrate.
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Aspirin resistance: position paper of the Working Group on Aspirin Resistance
Allan D. Michelson,Marco Cattaneo,John W. Eikelboom,Paul A. Gurbel,Kandice Kottke-Marchant,Thomas J. Kunicki,Fabio M. Pulcinelli,Chiara Cerletti,A. K. Rao +8 more
TL;DR: This work presents a meta-analysis of Platelet Function Studies and Hemostasis in relation to Thrombosis and Haemostasis that shows clear trends in prognosis and in particular in cases of high-risk individuals, where the prognosis for survival is poorer for those with high levels of Aspirin resistance.
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Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets.
TL;DR: Evidence is obtained that the IIb-IIIa complex exists in the membrane of intact nonstimulated platelets and that complex integrity is not affected by external calcium ion concentration.