Aspirin resistance: position paper of the Working Group on Aspirin Resistance
Allan D. Michelson,Marco Cattaneo,John W. Eikelboom,Paul A. Gurbel,Kandice Kottke-Marchant,Thomas J. Kunicki,Fabio M. Pulcinelli,Chiara Cerletti,A. K. Rao +8 more
TLDR
This work presents a meta-analysis of Platelet Function Studies and Hemostasis in relation to Thrombosis and Haemostasis that shows clear trends in prognosis and in particular in cases of high-risk individuals, where the prognosis for survival is poorer for those with high levels of Aspirin resistance.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2005-06-01 and is currently open access. It has received 329 citations till now. The article focuses on the topics: Drug resistance.read more
Citations
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Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
TL;DR: The article does not provide specific management recommendations; however, it does highlight important practical aspects related to antiplatelet therapy, including the optimal dose of aspirin, the variable balance of benefits and hazards in different clinical settings, and the issue of interindividual variability in response toAntiplatelet drugs.
American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
TL;DR: Hirsh et al. as discussed by the authors published the 8th edition of the Clinical of Chest Physicians Evidence-Based Parenteral Anticoagulants (8th Edition) Clinical Guidelines, 2008.
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A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
Marie Lordkipanidzé,Chantal Pharand,Erick Schampaert,Jacques Turgeon,Donald A. Palisaitis,Jean G. Diodati +5 more
TL;DR: Six major platelet function tests are not equally effective in measuring aspirin's antiplatelet effect and correlate poorly amongst themselves, and the clinical usefulness of the different assays to classify correctly patients as aspirin resistant remains undetermined.
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Platelet function monitoring in patients with coronary artery disease
TL;DR: Current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages are described, evidence for antiplatelet response variability and resistance is reviewed, and the potential pitfalls of monitoring Platelet function are discussed.
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Association of Laboratory-Defined Aspirin Resistance With a Higher Risk of Recurrent Cardiovascular Events: A Systematic Review and Meta-analysis
Jaapjan D. Snoep,Marcel M. C. Hovens,Jeroen Eikenboom,Johanna G. van der Bom,Menno V. Huisman +4 more
TL;DR: It is shown that patients biochemically identified as having laboratory aspirin resistance are more likely to also have "clinical resistance" to aspirin because they exhibit significantly higher risks of recurrent cardiovascular events compared with patients who are identified as (laboratory) aspirin sensitive.
References
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Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects
Carlo Patrono,Barry S. Coller,James E. Dalen,Valentin Fuster,Michael Gent,Laurence A. Harker,Jack Hirsh,Gerald Juergen Roth +7 more
TL;DR: Abbreviations: ACE trial 5 Acetylsalicylic Acid and Carotid Endarterectomy; CAPRIE study 5 Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events; CI 5 confidence interval; COX 5 cyclooxygenase; DVT 5 deep venous thrombosis; EPISTENT trial 5 Evaluation of Platelet IIb/IIIa Inhibitors for Stenting.
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Aspirin-Resistant Thromboxane Biosynthesis and the Risk of Myocardial Infarction, Stroke, or Cardiovascular Death in Patients at High Risk for Cardiovascular Events
TL;DR: It is raised the possibility that elevated urinary 11-dehydro thromboxane B2 levels identify patients who are relatively resistant to aspirin and who may benefit from additional antiplatelet therapies or treatments that more effectively block in vivo throm boxane production or activity.
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A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease.
TL;DR: This study demonstrates the natural history of aspirin resistance in a stable population, documenting a greater than threefold increase in the risk of major adverse events associated with aspirin resistance.
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Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
TL;DR: There is an expanding role for the combination of aspirin and clopidogrel in the long-term management of high-risk patients and the cardiovascular effects of selective and nonselective cyclooxygenase-2 inhibitors have been the subject of increasing attention.
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Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment.
TL;DR: Despite adequate pretreatment with clopidogrel, patients with aspirin resistance as measured by a point-of-care assay have an increased risk of myonecrosis following non-urgent PCI.