Thomas Kirchner

TL;DR: The differences between Western and Japanese pathologists in the diagnostic classification of gastrointestinal epithelial neoplastic lesions can be resolved largely by adopting the proposed terminology, which is based on cytological and architectural severity and invasion status.

TL;DR: An extended, integrated model that is consistent with all aspects of human tumour progression is suggested — the 'migrating cancer stem (MCS)-cell' concept.

TL;DR: The identification of the matrix metalloproteinase MMP-7 as another target gene of β-catenin/TCF-4 is reported, indicating that defects in the APC tumor suppressor gene may also have an influence on later steps of colon tumor progression.

TL;DR: It is suggested that in a sub-group of SLE patients, apoptotic cells are not properly cleared by tingible body macrophages of the GCs, and nuclear autoantigens bind to FDCs and may thus provide survival signals for autoreactive B cells.

TL;DR: Using immunohistochemistry, the distribution of overexpressed beta-Catenin within individual colorectal carcinomas was investigated and it was found that surrounding tissue at the invasion front can give signals to the tumor cells, leading to a nuclear translocation of beta- Catenin, where it may play a direct role in tumor invasion processes.