T
Thomas L. Kash
Researcher at University of North Carolina at Chapel Hill
Publications - 124
Citations - 7219
Thomas L. Kash is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Stria terminalis & Extended amygdala. The author has an hindex of 43, co-authored 110 publications receiving 5753 citations. Previous affiliations of Thomas L. Kash include Vanderbilt University & Cornell University.
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Journal ArticleDOI
Distinct extended amygdala circuits for divergent motivational states
Joshua H. Jennings,Dennis R. Sparta,Alice M. Stamatakis,Randall L. Ung,Kristen E. Pleil,Thomas L. Kash,Garret D. Stuber +6 more
TL;DR: Channelrhodopsin-2-assisted circuit mapping revealed that both BNST glutamatergic and GABAergic projections preferentially innervate postsynaptic non-dopaminergic VTA neurons, thus providing a mechanistic framework for in vivo circuit perturbations.
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Coupling of agonist binding to channel gating in the GABA A receptor
TL;DR: It is shown that optimal gating in the GABAA receptor, a member of the LGIC superfamily, is dependent on electrostatic interactions between the negatively charged Asp 57 and Asp 149 residues in extracellular loops 2 and 7, and the positively charged Lys 279 residue in the transmembrane 2–3 linker region of the α1-subunit.
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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior
Eyal Vardy,J. Elliott Robinson,Chia Li,Chia Li,Reid H.J. Olsen,Jeffrey F. DiBerto,Patrick M. Giguère,Flori M. Sassano,Xi Ping Huang,Hu Zhu,Daniel J. Urban,Kate L. White,Joseph E. Rittiner,Nicole A. Crowley,Kristen E. Pleil,Christopher M. Mazzone,Philip D. Mosier,Juan Song,Thomas L. Kash,C. J. Malanga,Michael J. Krashes,Michael J. Krashes,Bryan L. Roth +22 more
TL;DR: A structure-based approach is used to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template that is activated by the pharmacologically inert ligand salvinorin B (SALB) that robustly attenuated neuronal activity and modified behaviors.
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Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Catherine A. Marcinkiewcz,Christopher M. Mazzone,Giuseppe D'Agostino,Lindsay R. Halladay,J. Andrew Hardaway,Jeffrey F. DiBerto,Montserrat Navarro,Nathan W. Burnham,Claudia Cristiano,Cayce E. Dorrier,Gregory J. Tipton,Charu Ramakrishnan,Tamas Kozicz,Tamas Kozicz,Karl Deisseroth,Todd E. Thiele,Zoe A. McElligott,Andrew Holmes,Lora K. Heisler,Thomas L. Kash +19 more
TL;DR: An essential 5-HTDRN→CRFBNST circuit governing fear and anxiety underlies aversive behaviour following acute exposure to selective serotonin reuptake inhibitors (SSRIs), and provides a potential mechanistic explanation for the clinical observation of early adverse events to SSRI treatment in some patients with anxiety disorders.
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Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward
Ream Al-Hasani,Jordan G. McCall,Gunchul Shin,Adrian M. Gomez,Gavin P. Schmitz,Julio M. Bernardi,Chang O. Pyo,Sung Il Park,Catherine M. Marcinkiewcz,Nicole A. Crowley,Michael J. Krashes,Bradford B. Lowell,Thomas L. Kash,John A. Rogers,Michael R. Bruchas +14 more
TL;DR: Results show previously unknown discrete subregions of dynorphin-containing cells in the NAc shell that selectively drive opposing behaviors, which provides insight into motivated behaviors that are dysregulated in stress, reward, and psychiatric disease.