T
Thomas P. Zwaka
Researcher at University of Wisconsin-Madison
Publications - 19
Citations - 3359
Thomas P. Zwaka is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 8, co-authored 14 publications receiving 3230 citations. Previous affiliations of Thomas P. Zwaka include Wisconsin Alumni Research Foundation & University of Ulm.
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Journal ArticleDOI
BMP4 initiates human embryonic stem cell differentiation to trophoblast.
Ren-He Xu,Xin Chen,Dong S. Li,Rui Li,Gregory C. Addicks,Clay Glennon,Thomas P. Zwaka,James A. Thomson +7 more
TL;DR: Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor-beta (TGF-beta) superfamily, induces the differentiation of human ES cells to trophoblast.
Journal ArticleDOI
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells
Jonathan S. Draper,Kath Smith,Paul J. Gokhale,Harry Moore,Edna Maltby,Julie A. Johnson,Lorraine F. Meisner,Thomas P. Zwaka,James A. Thomson,Peter W. Andrews +9 more
TL;DR: It is suggested that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.
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Homologous recombination in human embryonic stem cells.
Thomas P. Zwaka,James A. Thomson +1 more
TL;DR: An electroporation approach is reported, based on the physical characteristics of human ES cells, that is used to successfully target HPRT1, the gene encoding hypoxanthine phosphoribosyltransferase-1 (H PRT1), and POU5F1,the gene encoding octamer-binding transcription factor 4 (Oct4; also known as POU domain, class 5, transcription factor 1 (POU5f1)).
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A germ cell origin of embryonic stem cells
TL;DR: Evidence is reviewed that the closest in vivo equivalent of an ES cell is an early germ cell, which is believed to most closely resemble pluripotent primitive ectoderm cells derived directly from the ICM.
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Differentiation of human embryonic stem cells occurs through symmetric cell division.
TL;DR: It is reported that human ES cells differentiate exclusively by symmetric cell division in each of four distinct differentiation conditions examined, which suggests that, in some respects, ES cells more closely resemble precursor or transit amplifying cells rather than adult stem cells.