J
Jonathan S. Draper
Researcher at McMaster University
Publications - 34
Citations - 5604
Jonathan S. Draper is an academic researcher from McMaster University. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 19, co-authored 33 publications receiving 5371 citations. Previous affiliations of Jonathan S. Draper include McMaster-Carr & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells
Jonathan S. Draper,Kath Smith,Paul J. Gokhale,Harry Moore,Edna Maltby,Julie A. Johnson,Lorraine F. Meisner,Thomas P. Zwaka,James A. Thomson,Peter W. Andrews +9 more
TL;DR: It is suggested that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.
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Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Jamie M. Sperger,Xin Chen,Jonathan S. Draper,Jessica E. Antosiewicz,Chris H. Chon,Sunita B. Jones,James D. Brooks,Peter W. Andrews,Patrick O. Brown,James A. Thomson +9 more
TL;DR: The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples, and 895 genes were identified that are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype.
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Surface antigens of human embryonic stem cells: changes upon differentiation in culture.
TL;DR: The surface antigen phenotype of a human embryonic stem (hES) cell line (H7) and the changes that occur upon differentiation induced by retinoic acid, hexamethylene bisacetamide and dimethylsulphoxide are analysed.
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Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens
J. K. Henderson,Jonathan S. Draper,H. S. Baillie,S. Fishel,James A. Thomson,Harry Moore,Peter W. Andrews +6 more
TL;DR: It is shown that human ES cells are characterized by the expression of the cell‐surface antigens, SSEA3, S SEA4, TRA‐1‐60, and TRA‐ 1‐81, and by the lack of SSEA1, and that inner cell mass cells of the human blastocyst express a similar antigen profile, in contrast to the corresponding Cells of the mouse embryo.
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Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
Amy Ralston,Brian J. Cox,Noriyuki Nishioka,Hiroshi Sasaki,Evelyn Chea,Peter J. Rugg-Gunn,Guoji Guo,Paul Robson,Jonathan S. Draper,Janet Rossant +9 more
TL;DR: It is suggested that Gata3 and Cdx2 can act in parallel pathways downstream of Tead4 to induce the expression of common and independent targets in the trophoblast lineage, whereas Oct4 is required for continued repression of trophOBlast fate in the embryonic lineage.