T
Thomas R. Broker
Researcher at University of Rochester
Publications - 65
Citations - 6503
Thomas R. Broker is an academic researcher from University of Rochester. The author has contributed to research in topics: Transcription (biology) & Gene. The author has an hindex of 41, co-authored 65 publications receiving 6359 citations. Previous affiliations of Thomas R. Broker include Cold Spring Harbor Laboratory & California Institute of Technology.
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An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA
TL;DR: Findings imply a new mechanism for the biosynthesis of Ad2 mRNA in mammalian cells which is complementary to sequences within the Ad2 genome which are remote from the DNA from which the main coding sequence of each mRNA is transcribed.
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Complex splicing patterns of RNAs from the early regions of adenovirus-2
TL;DR: From the large, complex arrays of composite RNA structures, numerous insights into the RNA splicing mechanisms were inferred.
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Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes.
Shinta Cheng,Delf-Christian Schmidt-Grimminger,Thomas Murant,Thomas R. Broker,Louise T. Chow +4 more
TL;DR: It is shown that an intact E7 gene of either high-risk or of low-risk HPV genotypes, under the control of its respective native enhancer-promoter, induced proliferating cell nuclear antigen (PCNAs) expression in the suprabasal cells of epithelial raft cultures of primary human foreskin keratinocytes (PHK).
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Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.
TL;DR: The interactions among the cis elements and trans factors of papillomaviruses are more conserved than expected from the other members of the papovavirus family, simian virus 40 and polyomavirus, for which large tumor antigen does not replicate a heterologous ori in either permissive or nonpermissive cells.
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A map of cytoplasmic RNA transcripts from lytic adenovirus type 2, determined by electron microscopy of RNA:DNA hybrids
TL;DR: Using electron microscopic RNA loop mapping to determine, to within 200 nucleotides, the chromosome coordinates of the 5′ and 3′ ends of adenovirus type 2 transcripts isolated from the cytoplasm of productively infected human KB cells, the most frequent late RNA loop occurred between coordinates 51.9 and 62.8.