T
Thomas Worzfeld
Researcher at University of Marburg
Publications - 48
Citations - 2038
Thomas Worzfeld is an academic researcher from University of Marburg. The author has contributed to research in topics: Semaphorin & Plexin. The author has an hindex of 24, co-authored 41 publications receiving 1672 citations. Previous affiliations of Thomas Worzfeld include Max Planck Society & Heidelberg University.
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Semaphorins and plexins as therapeutic targets
TL;DR: The functions of the mammalian semaphorin–plexin system as well as its role in diseases are summarized and emerging strategies to pharmacologically targetSemaphorins and plexins are discussed.
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The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Thomas Worzfeld,Elke Pogge von Strandmann,Magdalena Huber,Till Adhikary,Uwe Wagner,Silke Reinartz,Rolf Müller +6 more
TL;DR: Current knowledge is summarized and discussed on signaling networks formed by cytokines, lipids, and extracellular vesicles; the pathophysiologial roles of TAMs and T cells; the mechanism of transcoelomic metastasis; and the cell type selective processing of signals from the TME.
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ErbB-2 and Met Reciprocally Regulate Cellular Signaling via Plexin-B1
TL;DR: It is shown that Sema4D-induced activation and inactivation of RhoA require ErbB-2 and Met, respectively, and the exchange of the two receptor tyrosine kinases is sufficient to convert the cellular response to Sema 4D from pro- to anti-migratory and vice versa.
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G12/G13-mediated signalling in mammalian physiology and disease
TL;DR: This work focuses on recent progress made in the analyses of the in vivo functions of mammalian G(12)/G(13)-mediated signalling and reveals new insights into the in vitro functions of this G-protein family.
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Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo
Suhua Deng,Alexandra Hirschberg,Thomas Worzfeld,Junia Y. Penachioni,Alexander Korostylev,Jakub M. Swiercz,Peter Vodrazka,Olivier Mauti,Esther T. Stoeckli,Luca Tamagnone,Stefan Offermanns,Rohini Kuner +11 more
TL;DR: A key requirement is observed for Plexin-B2 in proliferation and migration of granule cell precursors in the developing dentate gyrus, olfactory bulb, and cerebellum, which reveals a key requirement in patterning of the vertebrate nervous system in vivo.