Tian Chen

TL;DR: A cis-regulatory role of noncoding intronic transcripts on their parent coding genes is suggested, which largely accumulates to its sites of transcription, associates with elongation Pol II machinery, and acts as a positive regulator of Pol II transcription.

TL;DR: It is demonstrated that a long noncoding RNA, CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC, and this lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping.

TL;DR: It is observed that ADAR1 deficiency in human embryonic stem cells (hESCs) significantly affected hESC differentiation and neural induction with widespread changes in mRNA and miRNA expression, including upregulation of self-renewal-related miRNAs, such as miR302s.

TL;DR: Comparative transcriptomes of non-polyadenylated RNAs among human, rhesus and mouse revealed that the expression of sno-lncRNAs is species-specific and that their processing is closely linked to alternative splicing of their parent genes.

TL;DR: A new strategy to accurately predict constitutive RNA editing sites from publicly available human RNA-seq datasets in the absence of relevant genomic sequences is developed and new parameters are established to increase the ability to map mismatches and to minimize sequencing/mapping errors and unreported genome variations.