Q
Qing-Fei Yin
Researcher at Laboratory of Molecular Biology
Publications - 11
Citations - 3348
Qing-Fei Yin is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: RNA & Small nucleolar RNA. The author has an hindex of 10, co-authored 11 publications receiving 2621 citations. Previous affiliations of Qing-Fei Yin include Chinese Academy of Sciences.
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Journal ArticleDOI
Circular Intronic Long Noncoding RNAs
Yang Zhang,Xiao-Ou Zhang,Tian Chen,Jian-Feng Xiang,Qing-Fei Yin,Yu-Hang Xing,Shanshan Zhu,Li Yang,Ling-Ling Chen +8 more
TL;DR: A cis-regulatory role of noncoding intronic transcripts on their parent coding genes is suggested, which largely accumulates to its sites of transcription, associates with elongation Pol II machinery, and acts as a positive regulator of Pol II transcription.
Journal ArticleDOI
Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
Jian-Feng Xiang,Qing-Fei Yin,Tian Chen,Yang Zhang,Xiao-Ou Zhang,Zheng Wu,Shaofeng Zhang,Hai-Bin Wang,Junhui Ge,Xuhua Lu,Li Yang,Ling-Ling Chen +11 more
TL;DR: It is demonstrated that a long noncoding RNA, CCAT1-L, is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC, and this lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping.
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Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection
Xiang Li,Chu-Xiao Liu,Wei Xue,Yang Zhang,Shan Jiang,Qing-Fei Yin,Jia Wei,Run-Wen Yao,Li Yang,Li Yang,Ling-Ling Chen,Ling-Ling Chen +11 more
TL;DR: Using genome-wide siRNA screening that targets all human unique genes and an efficient circRNA expression reporter, double-stranded RNA-binding domain containing immune factors NF90/NF110 are identified as key regulators in circRNA biogenesis and function in viral infection.
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Long Noncoding RNAs with snoRNA Ends
Qing-Fei Yin,Li Yang,Yang Zhang,Jian-Feng Xiang,Yue-Wei Wu,Gordon G. Carmichael,Ling-Ling Chen +6 more
TL;DR: The discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs that are processed on both ends by the snoRNA machinery, implicate a previously unannotated class of lnc RNAs in the molecular pathogenesis of PWS.
Journal ArticleDOI
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins
Huang Wu,Qing-Fei Yin,Zheng Luo,Run-Wen Yao,Run-Wen Yao,Chuan-Chuan Zheng,Chuan-Chuan Zheng,Jun Zhang,Jian-Feng Xiang,Li Yang,Ling-Ling Chen,Ling-Ling Chen,Ling-Ling Chen +12 more
TL;DR: The results expand the diversity of lncRNAs and provide additional insights into PWS pathogenesis as well as altered patterns of RBPs binding and alternative splicing.