Tianfu Zhang

TL;DR: These far-red and NIR AIEgens are excellent candidates for the two-photon fluorescence imaging of LDs or mitochondria and organelle-targeting photodynamic cancer therapy and can efficiently generate singlet oxygen upon light irradiation for the photodynamic ablation of cancer cells.

TL;DR: By molecular charge engineering, it is proved that the in situ translocation of TPE-4EP+ is mainly attributed to the enhanced interaction with DNA imposed by its multivalent positive charge.

TL;DR: Inspired by the concept of Big Data Analysis (BDA), these fluorescence signals were further transformed into a unique fingerprint of cells via linear discriminant analysis (LDA) and realized the veracious identification between a normal cell line, two cancer cell lines and two metastasize cancer cell Lines at qualitative analysis.

Abstract: The emergence of the concept of aggregation-induced emission (AIE) has opened new opportunities in many research areas, such as biopsy analysis, biological processes monitoring, and elucidation of key physiological and pathological behaviors. As a new class of luminescent materials, AIE luminogens (AIEgens) possess many prominent advantages such as tunable molecular structures, high molar absorptivity, high brightness, large Stokes shift, excellent photostability, and good biocompatibility. The past two decades have witnessed a dramatic growth of research interest in AIE, and many AIE-based bioprobes with excellent performance have been widely explored in biomedical fields. This review summarizes some of the latest advancements of AIE molecular probes and AIE nanoparticles (NPs) with regards to biomedical and healthcare applications. According to the research areas, the review is divided into five sections, which are imaging and identification of cells and bacteria, photodynamic therapy, multimodal theranostics, deep tissue imaging, and fluorescence-guided surgery. The challenges and future opportunities of AIE materials in the advanced biomedical fields are briefly discussed. In perspective, the AIE-based bioprobes play vital roles in the exploration of advanced bioapplications for the ultimate goal of addressing more healthcare issues by integrating various cutting-edge modalities and techniques.

TL;DR: In this paper, two red luminogens with aggregation-induced emission (AIE) characteristics based on simple D-A structures with high performance in the film state are explored, and they exhibit CIE coordinates of (0.63, 0.36) and