T
Tiffany Hung
Researcher at Genentech
Publications - 19
Citations - 9008
Tiffany Hung is an academic researcher from Genentech. The author has contributed to research in topics: Histone H3 & Histone code. The author has an hindex of 12, co-authored 18 publications receiving 8128 citations. Previous affiliations of Tiffany Hung include Howard Hughes Medical Institute & Stanford University.
Papers
More filters
Journal ArticleDOI
The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression
Tiffany Hung,Gabriel A. Pratt,Balaji Sundararaman,Michael J. Townsend,Christina Chaivorapol,Tushar Bhangale,R. R. Graham,Ward Ortmann,Lindsey A. Criswell,Gene W. Yeo,Gene W. Yeo,Gene W. Yeo,Timothy W. Behrens +12 more
TL;DR: Findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu Retroelements.
Journal ArticleDOI
ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation
Tiffany Hung,Olivier Binda,Karen S. Champagne,Alex J. Kuo,Kyle Johnson,Howard Y. Chang,Matthew D. Simon,Tatiana G. Kutateladze,Or Gozani +8 more
TL;DR: A mechanism for brokering crosstalk between H3K4 methylation and H3 acetylation is demonstrated and a molecular link between chromatin modulation and tumor suppressor mechanisms is revealed.
Journal ArticleDOI
An inducible long noncoding RNA amplifies DNA damage signaling.
Adam M. Schmitt,Julia T. Garcia,Tiffany Hung,Ryan A. Flynn,Ying Shen,Kun Qu,Alexander Y. Payumo,Ashwin Peres-da-Silva,Daniela Kenzelmann Broz,Rachel Baum,Shuling Guo,James K. Chen,Laura D. Attardi,Howard Y. Chang +13 more
TL;DR: Dino knockout or promoter inactivation in mice dampened p53 signaling and ameliorated acute radiation syndrome in vivo, demonstrating that inducible lncRNA can create a feedback loop with its cognate transcription factor to amplify cellular signaling networks.
Journal ArticleDOI
HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail
Nehmé Saksouk,Nikita Avvakumov,Karen S. Champagne,Tiffany Hung,Yannick Doyon,Christelle Cayrou,Eric Paquet,Mukta Ullah,Anne-Julie Landry,Valérie Côté,Xiang-Jiao Yang,Or Gozani,Tatiana G. Kutateladze,Jacques Côté +13 more
TL;DR: The PHD finger domains are essential in regulating chromatin binding and substrate specificity of HBO1 HAT complexes, as well as cell growth as mentioned in this paper, and they have been shown to play critical roles in gene regulation and DNA replication.
Journal ArticleDOI
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor
Pedro V. Peña,Robert A. Hom,Tiffany Hung,H. Lin,Alex J. Kuo,R.P.C. Wong,Oksana M. Subach,K.S. Champagne,Rui Zhao,Vladislav V. Verkhusha,G. Li,Or Gozani,Tatiana G. Kutateladze +12 more
TL;DR: The W235A mutant, overexpressed in the stable clones of melanoma cells or in HT1080 cells, was unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis, indicating that H3K4me3 binding is necessary for these biological functions of ING1.