T
Tiffany Thomas
Researcher at Columbia University
Publications - 53
Citations - 2238
Tiffany Thomas is an academic researcher from Columbia University. The author has contributed to research in topics: Apolipoprotein B & Medicine. The author has an hindex of 24, co-authored 45 publications receiving 1422 citations. Previous affiliations of Tiffany Thomas include Tufts University & Columbia University Medical Center.
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Journal ArticleDOI
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Tiffany Thomas,Davide Stefanoni,Julie A. Reisz,Travis Nemkov,Lorenzo Bertolone,Richard O. Francis,Krystalyn E. Hudson,James C. Zimring,Kirk C. Hansen,Eldad A. Hod,Steven L. Spitalnik,Angelo D'Alessandro +11 more
TL;DR: This initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.
Journal ArticleDOI
Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans
Gissette Reyes-Soffer,Marianna Pavlyha,Colleen Ngai,Tiffany Thomas,Stephen Holleran,Rajasekhar Ramakrishnan,Wahida Karmally,Renu Nandakumar,Nelson Fontanez,Joseph C. Obunike,Santica M. Marcovina,Alice H. Lichtenstein,Nirupa R Matthan,James Matta,Magali Maroccia,Frederic Becue,Franck Poitiers,Brian Swanson,Lisa Cowan,William J. Sasiela,Howard K. Surks,Henry N. Ginsberg +21 more
TL;DR: Results are consistent with increases in LDL receptors available to clear IDL and LDL from blood during PCSK9 inhibition, and suggest that increased LDL receptors may also play a role in the reduction of plasma Lp(a) levels.
Journal ArticleDOI
Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients.
Tiffany Thomas,Davide Stefanoni,Monika Dzieciatkowska,Aaron Issaian,Travis Nemkov,Ryan C. Hill,Richard O. Francis,Krystalyn E. Hudson,Paul W. Buehler,James C. Zimring,Eldad A. Hod,Kirk C. Hansen,Steven L. Spitalnik,Angelo D'Alessandro +13 more
TL;DR: A significant impact of SARS-CoV-2 infection on RBC structural membrane homeostasis at the protein and lipid levels is suggested.
Journal ArticleDOI
Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level.
Angelo D'Alessandro,Tiffany Thomas,Monika Dzieciatkowska,Ryan C. Hill,Richard O. Francis,Krystalyn E. Hudson,James C. Zimring,Eldad A. Hod,Steven L. Spitalnik,Kirk C. Hansen +9 more
TL;DR: This study provides the first proteomics analysis of sera from COVID-19 patients, stratified by circulating levels of IL-6, and correlated to markers of inflammation and renal function, and identified significant dysregulation in serum levels of various coagulation factors, accompanied by increased levels of antifibrinolytic components, including several serine protease inhibitors (SERPINs).
Journal ArticleDOI
Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA.
Scott M. Turner,Elizabeth Murphy,Richard A. Neese,Fernando Antelo,Tiffany Thomas,A. Agarwal,C. Go,Marc K. Hellerstein +7 more
TL;DR: The hypothesis that mesenteric TG is more lipolytically active than other depots, previously difficult to prove by isotope dilution techniques, was confirmed by this label incorporation approach.