T
Tim Schedl
Researcher at Washington University in St. Louis
Publications - 123
Citations - 11242
Tim Schedl is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Caenorhabditis elegans & Germline. The author has an hindex of 55, co-authored 114 publications receiving 10059 citations. Previous affiliations of Tim Schedl include University of Wisconsin-Madison & University at Albany, SUNY.
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Journal ArticleDOI
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Tina L. Gumienny,Tina L. Gumienny,Enrico Brugnera,Annie-Carole Tosello-Trampont,Jason M. Kinchen,Jason M. Kinchen,Lisa B. Haney,Kiyoji Nishiwaki,Scott F. Walk,Michael E. Nemergut,Ian G. Macara,Ross Francis,Tim Schedl,Yi Qin,Linda Van Aelst,Linda Van Aelst,Michael O. Hengartner,Michael O. Hengartner,Kodimangalam S. Ravichandran +18 more
TL;DR: These studies identify CED-12/ELMO as an upstream regulator of Rac1 that affects engulfment and cell migration from C. elegans to mammals.
Journal ArticleDOI
On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans
TL;DR: By systematically altering the germ cell contents of the hermaphrodite using mutant strains, this work has uncovered evidence of four cell-cell interactions that regulate maturation and ovulation in Caenorhabditis elegans.
Journal ArticleDOI
Whole-genome sequencing and variant discovery in C. elegans.
LaDeana W. Hillier,Gabor T. Marth,Aaron R. Quinlan,David J. Dooling,Ginger A. Fewell,Derek Barnett,Paul Fox,Jarret Glasscock,Matthew T. Hickenbotham,Weichun Huang,Vincent Magrini,Ryan Richt,Sacha N. Sander,Donald A. Stewart,Michael Strömberg,Eric F. Tsung,Todd Wylie,Tim Schedl,Richard K. Wilson,Elaine R. Mardis +19 more
TL;DR: This study sequenced a Caernohabditis elegans N2 Bristol strain isolate and compared the reads to the reference genome to characterize the data and to evaluate coverage and representation, demonstrating the utility of massively parallel short read sequencing for whole genome resequencing and for accurate discovery of genome-wide polymorphisms.
Journal ArticleDOI
A Sperm Cytoskeletal Protein That Signals Oocyte Meiotic Maturation and Ovulation
Michael A. Miller,Viet Q. Nguyen,Min-Ho Lee,Mary E. Kosinski,Tim Schedl,Richard M. Caprioli,David Greenstein +6 more
TL;DR: It is shown that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction, and MSP also functions in sperm locomotion, playing a role analogous to actin.
Journal ArticleDOI
Gld-1, a Tumor Suppressor Gene Required for Oocyte Development in Caenorhabditis Elegans
TL;DR: It is shown that gld-1(+) has an additional nonessential role in germline sex determination: promotion of hermaphrodite spermatogenesis and this function is inferred from a haplo-insufficient phenotype and from the properties of gain-of-function gll-1 mutations that cause alterations in the sexual identity of germ cells.