Tim Segers

TL;DR: It is expected that for a successful development of future opportunities, such as ultrasound molecular imaging and therapeutic applications using microbubbles, new creative developments in microbubble engineering and production dedicated to further optimizingmicrobubble performance are required, and that they cannot rely on bubble technology developed more than 3 decades ago.

TL;DR: This review aims at connecting the knowledge gained from fundamental microbubble studies to the therapeutic efficacy seen in in vitro and in vivo studies, with an emphasis on a better understanding of the response of a microbubbles upon exposure to ultrasound and its interaction with cells and tissues.

TL;DR: This review of theoretical models that have been proposed to study and predict the behavior of ultrasound contrast agents in the form of microscopic bubbles coated by a biocompatible shell concludes with promising directions for the modeling and development of novel agents.

TL;DR: The developments in agents for diagnostic, therapeutic and "theranostic" applications; novel manufacturing techniques; and the opportunities and challenges for their commercial and clinical translation are reviewed.

TL;DR: This work demonstrates high-throughput production of clinically relevant monodisperse contrast microbubbles with excellent control over phospholipid monolayer elasticity and microbubble resonance.