N
Nico de Jong
Researcher at Erasmus University Rotterdam
Publications - 395
Citations - 13568
Nico de Jong is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Microbubbles & Transducer. The author has an hindex of 59, co-authored 359 publications receiving 12083 citations. Previous affiliations of Nico de Jong include Erasmus University Medical Center & Delft University of Technology.
Papers
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Journal ArticleDOI
A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture
Philippe Marmottant,Philippe Marmottant,Sander van der Meer,M. Emmer,Michel Versluis,Nico de Jong,Nico de Jong,Sascha Hilgenfeldt,Sascha Hilgenfeldt,Detlef Lohse +9 more
TL;DR: In this paper, the authors present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble, including buckling radius, the compressibility of the shell, and a break-up shell tension.
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Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation.
Annemieke van Wamel,Klazina Kooiman,Miranda Harteveld,M. Emmer,Folkert J. ten Cate,Michel Versluis,Nico de Jong,Nico de Jong +7 more
TL;DR: It is identified that microbubbles are crucial to enhance transient cell membrane permeability and permeability of individual cells is increased.
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Sonoporation from Jetting Cavitation Bubbles
Claus-Dieter Ohl,Manish Arora,Roy Ikink,Nico de Jong,Michel Versluis,Michael Delius,Detlef Lohse +6 more
TL;DR: It is found that the nonspherical collapse of bubbles near to the boundary is responsible for cell detachment, and high-speed photography reveals that a wall bounded flow leads to the detachment of cells.
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Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation
Bernadet D. M. Meijering,Lynda J. M. Juffermans,Annemieke van Wamel,Robert H. Henning,Inge S. Zuhorn,M. Emmer,Amanda M. G. Versteilen,Walter Paulus,Wiek H. van Gilst,Klazina Kooiman,Nico de Jong,René J. P. Musters,Leo E. Deelman,Otto Kamp +13 more
TL;DR: In addition to triggering endocytosis, UMTD also evoked transient pore formation, as demonstrated by the influx of calcium ions and cellular release of preloaded dextrans after US and microbubble exposure.
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Ultrasound contrast imaging: current and new potential methods
TL;DR: A complete understanding of the US-contrast agent interaction is essential for further improvements of current detection methods, and the development of new imaging techniques.