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Irmgard Förster
Researcher at University of Bonn
Publications - 118
Citations - 18175
Irmgard Förster is an academic researcher from University of Bonn. The author has contributed to research in topics: Immune system & Proinflammatory cytokine. The author has an hindex of 47, co-authored 113 publications receiving 16317 citations. Previous affiliations of Irmgard Förster include Ludwig Maximilian University of Munich & Technische Universität München.
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Journal ArticleDOI
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.
TL;DR: The generation of mice that express Cre in myeloid cells due to targeted insertion of the cre cDNA into their endogenous M lysozyme locus is reported, allowing for both specific and highly efficient Cre–mediated deletion of loxP–flanked target genes in myELoid cells.
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HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Thorsten Cramer,Yuji Yamanishi,Björn E. Clausen,Irmgard Förster,Rafal Pawlinski,Nigel Mackman,Volker H. Haase,Rudolf Jaenisch,Maripat Corr,Victor Nizet,Gary S. Firestein,Hans-Peter Gerber,Napoleone Ferrara,Randall S. Johnson +13 more
TL;DR: It is found that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a mechanism independent of VEGF, and its direct regulation of survival and function in the inflammatory microenvironment is demonstrated.
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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
Kiyoshi Takeda,Björn E. Clausen,Tsuneyasu Kaisho,Tohru Tsujimura,Nobuyuki Terada,Irmgard Förster,Shizuo Akira +6 more
TL;DR: Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10, which contributes to chronic enterocolitis with age.
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SOCS3 negatively regulates IL-6 signaling in vivo.
Ben A. Croker,Danielle L. Krebs,Jian-Guo Zhang,Sam Wormald,Tracy A. Willson,Edouard G. Stanley,Lorraine Robb,Christopher J. Greenhalgh,Irmgard Förster,Björn E. Clausen,Nicos A. Nicola,Donald Metcalf,Douglas J. Hilton,Andrew W. Roberts,Warren S. Alexander +14 more
TL;DR: It is shown that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation of STAT1 after stimulation with interferon-γ (IFN-γ).
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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Greta Guarda,Marion Braun,Francesco Staehli,Aubry Tardivel,Chantal Mattmann,Irmgard Förster,Matthias Farlik,Thomas Decker,Renaud Du Pasquier,Pedro Romero,Jürg Tschopp +10 more
TL;DR: This article showed that type I interferon (IFN) inhibited interleukin-1 (IL-1) production through two distinct mechanisms: STAT1 transcription factor and autocrine IL-10 signaling.