T
Timo Hamers
Researcher at VU University Amsterdam
Publications - 94
Citations - 4828
Timo Hamers is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Medicine & Bioassay. The author has an hindex of 34, co-authored 85 publications receiving 4248 citations. Previous affiliations of Timo Hamers include Wageningen University and Research Centre & Delft University of Technology.
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Journal ArticleDOI
In Vitro Profiling of the Endocrine-Disrupting Potency of Brominated Flame Retardants
Timo Hamers,Jorke H. Kamstra,Edwin Sonneveld,Albertinka J. Murk,Monique H. A. Kester,Patrik L. Andersson,Juliette Legler,Abraham Brouwer +7 more
TL;DR: For some BFRs, the potency to induce AR antagonism, E2SULT inhibition, and TTR competition was higher than for natural ligands or clinical drugs used as positive controls, which support further investigation of the potential ED effects of these environmentally relevant B FRs in man and wildlife.
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Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin.
Jana M. Weiss,Patrik L. Andersson,Marja H. Lamoree,Pim E.G. Leonards,Stefan P.J. van Leeuwen,Timo Hamers +5 more
TL;DR: Competitive binding of PFCs to TTR, as observed for human TTR in the present study, may explain altered thyroid hormone levels described for PFC-exposed rats and monkeys.
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Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
Timo Hamers,Jorke H. Kamstra,Edwin Sonneveld,Albertinka J. Murk,Theo J. Visser,Martin van Velzen,Abraham Brouwer,Åke Bergman +7 more
TL;DR: In this study, the endocrine-disrupting potency of metabolites from brominated flame retardants (BFRs) was determined and internal exposure to BFR metabolites may significantly contribute to the overall risk of endocrine disruption.
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Levels of hexabromocyclododecane in harbor porpoises and common dolphins from Western European Seas, with evidence for stereoisomer-specific biotransformation by cytochrome P450
Bart N. Zegers,Anchelique Mets,Ronald van Bommel,Chris Minkenberg,Timo Hamers,Jorke H. Kamstra,Graham J. Pierce,Jan P. Boon +7 more
TL;DR: It is proposed that biotransformation by the cytochrome P450 system is also the most likely process to explain the exclusive accumulation of alpha-HBCD in harbor porpoise and common dolphin from different European seas.
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A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in wistar rats
Leo T.M. van der Ven,Aart Verhoef,Ton van de Kuil,Wout Slob,Pim E.G. Leonards,Theo J. Visser,Timo Hamers,Maria Herlin,Helen Håkansson,Hanna Olausson,Aldert H. Piersma,Josephus G. Vos +11 more
TL;DR: A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune parameters was performed with hexabromocyclododecane (HBCD).