M
Monique H. A. Kester
Researcher at Erasmus University Rotterdam
Publications - 24
Citations - 3657
Monique H. A. Kester is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Deiodinase & Sulfation. The author has an hindex of 22, co-authored 24 publications receiving 3429 citations. Previous affiliations of Monique H. A. Kester include Erasmus University Medical Center.
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Journal ArticleDOI
In Vitro Profiling of the Endocrine-Disrupting Potency of Brominated Flame Retardants
Timo Hamers,Jorke H. Kamstra,Edwin Sonneveld,Albertinka J. Murk,Monique H. A. Kester,Patrik L. Andersson,Juliette Legler,Abraham Brouwer +7 more
TL;DR: For some BFRs, the potency to induce AR antagonism, E2SULT inhibition, and TTR competition was higher than for natural ligands or clinical drugs used as positive controls, which support further investigation of the potential ED effects of these environmentally relevant B FRs in man and wildlife.
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Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
Edith C. H. Friesema,Annette Grueters,Heike Biebermann,Heiko Krude,Arpad von Moers,Maarten Reeser,Timothy Barrett,Edna E. Mancilla,Johan Svensson,Monique H. A. Kester,George G. J. M. Kuiper,Sahila Balkassmi,André G. Uitterlinden,Josef Koehrle,Patrice Rodien,Andrew P. Halestrap,Theo J. Visser +16 more
TL;DR: It is suggested that this novel syndrome of X-linked psychomotor retardation is due to a defect in T3 entry into neurons through MCT8, resulting in impaired T3 action and metabolism.
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Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs
Monique H. A. Kester,S. Bulduk,Dick Tibboel,Walter Meinl,Hansruedi Glatt,Charles N. Falany,Michael W.H. Coughtrie,Åke Bergman,Stephen Safe,George G. J. M. Kuiper,A.G. Schuur,A. Brouwer,Theo J. Visser +12 more
TL;DR: It is demonstrated that various environmentally relevant PCB-OHs are extremely potent inhibitors of human estrogen sulfotransferase, strongly suggesting that they indirectly induce estrogenic activity by increasing estradiol bioavailability in target tissues.
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Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas
Monique H. A. Kester,Raquel Martínez de Mena,María Jesús Obregón,Danijela Marinkovic,Allan G. Howatson,Theo J. Visser,Robert Hume,Gabriella Morreale de Escobar +7 more
TL;DR: The hypothesis that T(3) is required by the human cerebral cortex before midgestation, when mother is the only source of T(4) is supported, and D3 protects brain regions from excessive T( 3) until differentiation is required.
Journal ArticleDOI
Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10.
Edith C. H. Friesema,Jurgen Jansen,Jan-willem Jachtenberg,W. Edward Visser,Monique H. A. Kester,Theo J. Visser +5 more
TL;DR: HMCT10 is at least as active a thyroid hormone transporter as hMCT8, and that both transporters facilitate iodothyronine uptake as well as efflux.