J
Jean M. Whaley
Researcher at Bristol-Myers Squibb
Publications - 44
Citations - 5088
Jean M. Whaley is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Diabetes mellitus & Dapagliflozin. The author has an hindex of 24, co-authored 41 publications receiving 4696 citations. Previous affiliations of Jean M. Whaley include Harvard University.
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Journal ArticleDOI
Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes
Wei Meng,Bruce A. Ellsworth,Alexandra A. Nirschl,P.J. McCann,Manorama Patel,Ravindar N. Girotra,Gang Wu,Philip M. Sher,Eamonn P. Morrison,Scott A. Biller,Robert Zahler,Prashant P. Deshpande,Annie Pullockaran,Deborah Hagan,Nathan Morgan,Joseph R. Taylor,Mary T. Obermeier,William G. Humphreys,Ashish Khanna,Lorell Discenza,James G. Robertson,Aiying Wang,Songping Han,John R. Wetterau,Evan B. Janovitz,Oliver P. Flint,Jean M. Whaley,William N. Washburn +27 more
TL;DR: The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic streptozotocin (STZ) rats.
Journal ArticleDOI
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.
Berton Zbar,Takeshi Kishida,F. Chen,Laura S. Schmidt,Eamonn R. Maher,Frances M. Richards,P A Crossey,Andrew R. Webster,Nabeel A. Affara,Malcolm A. Ferguson-Smith,Hiltrud Brauch,Damjan Glavač,Hartmut P. H. Neumann,Sam Tisherman,John J. Mulvihill,David J. Gross,Taro Shuin,Jean M. Whaley,Berndt Seizinger,Nickolai Kley,Sylviane Olschwang,Cécile Boisson,Stéphane Richard,C.H.M. Lips,W. Marston Linehan,Michael I. Lerman +25 more
TL;DR: The catalog of VHL germline mutations with phenotype information should be useful for diagnostic and prognostic studies of V HL and for studies of genotype‐phenotype correlations in VHL.
Journal ArticleDOI
The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix
Michael Ohh,Robert L. Yauch,Kim M. Lonergan,Jean M. Whaley,Anat Stemmer-Rachamimov,David N. Louis,Brian J. Gavin,Nikolai Kley,William G. Kaelin,William G. Kaelin,Othon Iliopoulos +10 more
TL;DR: Data support a direct role of pVHL in fibronectin matrix assembly and assembly by VHL-/- mouse embryos and mouse embryo fibroblasts, unlike their VHL+/+ counterparts, was grossly impaired.
Journal ArticleDOI
SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule
Volker Vallon,Kenneth A. Platt,Robyn Cunard,Jana Schroth,Jean M. Whaley,Scott C. Thomson,Hermann Koepsell,Timo Rieg +7 more
TL;DR: It is demonstrated that SGLT2 mediates glucose re absorption in the early proximal tubule and most of the glucose reabsorption by the kidney, overall, which mimics and explains the glucosuric phenotype of individuals carrying SLC5A2 mutations.
Journal ArticleDOI
Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.
Anil G. Menon,Kevin M. Anderson,V M Riccardi,Richard Y. Chung,Jean M. Whaley,David W. Yandell,G. E. Farmer,Richard N. Freiman,Jeng-Shin Lee,Fugen Li +9 more
TL;DR: The formation of malignant neurofibrosarcomas may result from several independent genetic events including mutation of the NF1 gene, whose mechanism of tumorigenesis remains uncertain, and subsequent loss of a "tumor suppressor" gene on 17p, most likely p53.