T
Timothy Evans
Researcher at University of California, San Francisco
Publications - 24
Citations - 1623
Timothy Evans is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Patched & Endosome. The author has an hindex of 15, co-authored 23 publications receiving 1544 citations. Previous affiliations of Timothy Evans include Cooperative Research Centre & University of Queensland.
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Journal ArticleDOI
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
Edwina Wright,Murray Hargrave,Jeffrey H. Christiansen,Leanne Cooper,Jutta Kun,Timothy Evans,Uma Gangadharan,Andy Greenfield,Peter Koopman +8 more
TL;DR: The expression pattern and chromosomal location of Sox9 suggest that it may be the gene defective in the mouse skeletal mutant Tail–short, a potential animal model for campomelic dysplasia.
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Isolation and Characterization of Human Patched 2 (PTCH2), a Putative Tumour Suppressor Gene in Basal Cell Carcinoma and Medulloblastoma on Chromosome 1p32
Ian M. Smyth,Monica Narang,Timothy Evans,Cornelia Heimann,Yusuke Nakamura,Georgia Chenevix-Trench,Torsten Pietsch,Carol Wicking,Brandon J. Wainwright +8 more
TL;DR: The genomic structure ofPTCH2 is characterized and single-stranded conformational polymorphism analysis is used to search for mutations in PTCH2 in NBCCS patients, basal cell carcinomas and in medulloblastomas, suggesting that the gene plays a role in the development of some tumours.
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Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.
TL;DR: Analysis of patched distribution by light and immunoelectron microscopy revealed it is primarily localized to endosomal elements, including transferrin receptor‐positive early endosomes and putative endosome carrier vesicles and, to a lesser extent, with LBPA‐positive lateendosomes, but was excluded from the plasma membrane.
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CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer
Carol Wicking,Lisa A. Simms,Timothy Evans,Michael Walsh,Kallayanee Chawengsaksophak,Felix Beck,Georgia Chenevix-Trench,Joanne P. Young,Jeremy R. Jass,Barbara A. Leggett,Brandon J. Wainwright +10 more
TL;DR: A survey of DNA from 85 colorectal tumours revealed that one with extensive microsatellite instability (RER+ phenotype) has mutations in both alleles of CDX2, consistent with those found in RER+ tumours.
Journal ArticleDOI
Scube2 mediates Hedgehog signalling in the zebrafish embryo.
Georgina E Hollway,John C. Maule,Philippe Gautier,Timothy Evans,David G Keenan,Claudia Lohs,Danielle Fischer,Carol Wicking,Peter D. Currie +8 more
TL;DR: It is shown that scube2 has homology to cubilin, which encodes an endocytic receptor involved in protein trafficking suggesting a possible mode of function for Scube2 during HH signal transduction.