T
Timothy P. Cripe
Researcher at Nationwide Children's Hospital
Publications - 156
Citations - 5190
Timothy P. Cripe is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Oncolytic virus & Cancer. The author has an hindex of 42, co-authored 139 publications receiving 4436 citations. Previous affiliations of Timothy P. Cripe include Cincinnati Children's Hospital Medical Center & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
Walter J. Jessen,Shyra J. Miller,Edwin Jousma,Jianqiang Wu,Tilat A. Rizvi,Meghan E. Brundage,David Eaves,Brigitte C. Widemann,Mi-Ok Kim,Eva Dombi,Jessica Sabo,Atira Hardiman Dudley,Michiko Niwa-Kawakita,Grier P. Page,Marco Giovannini,Bruce J. Aronow,Timothy P. Cripe,Nancy Ratner +17 more
TL;DR: It is demonstrated that deregulated Ras/ERK signaling is critical for the growth of NF1 peripheral nerve tumors and provide a strong rationale for testing MEK inhibitors in NF1 clinical trials.
Journal ArticleDOI
Prognostic factors and outcomes for osteosarcoma: an international collaboration.
Emilios E. Pakos,Andreas D. Nearchou,Robert J. Grimer,Haris D. Koumoullis,Adesegun Abudu,Jos A.M. Bramer,Lee Jeys,Alessandro Franchi,Guido Scoccianti,Domenico Andrea Campanacci,Rodolfo Capanna,Jorge Aparicio,Marie Dominique Tabone,Gerold Holzer,Fashid Abdolvahab,Philipp T. Funovics,Martin Dominkus,Inci Ergurhan Ilhan,Su Gülsün Berrak,Ana Patiño-García,Luis Sierrasesúmaga,Mikel San-Julian,Moira Garraus,Antonio Sergio Petrilli,Reynaldo Jesus Garcia Filho,Carla Renata Pacheco Donato Macedo,Maria Teresa de Seixas Alves,Sven Seiwerth,Rajaram Nagarajan,Timothy P. Cripe,John P. A. Ioannidis,John P. A. Ioannidis +31 more
TL;DR: The mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments,Use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate.
Journal Article
Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.
Timothy P. Cripe,Edward J. Dunphy,Alison D. Holub,Arvind Saini,Neeti Vasi,Yonatan Y. Mahller,Margaret H. Collins,Jean D. Snyder,Victor Krasnykh,David T. Curiel,Thomas J. Wickham,James DeGregori,Jeffrey M. Bergelson,Mark A. Currier +13 more
TL;DR: Stable transduction of the cDNA for CAR enabled both efficient Ad gene transfer and oncolysis for otherwise resistant RMS cells, suggesting that poor CAR expression is the limiting feature.
Journal ArticleDOI
Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus
Yonatan Y. Mahller,Jon P. Williams,William H. Baird,Bryan Mitton,Bryan Mitton,Jonathan Grossheim,Yoshinaga Saeki,Jose A. Cancelas,Nancy Ratner,Timothy P. Cripe +9 more
TL;DR: Human neuroblastoma contains tumor initiating cells that may be effectively targeted by an oncolytic virus, which may represent an effective therapy for chemotherapy-resistant tumor initiate cells.
Journal ArticleDOI
A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
Justine R. Stehn,Nikolas K. Haass,Nikolas K. Haass,Nikolas K. Haass,Theresa Bonello,Melissa Desouza,Gregg Kottyan,Herbert R. Treutlein,Jun Zeng,Paula R. B. B. Nascimento,Vanessa B. Sequeira,Tanya L. Butler,Munif Allanson,Thomas Fath,Timothy A. Hill,Adam McCluskey,Galina Schevzov,Stephen J. Palmer,Edna C. Hardeman,David S. Winlaw,Vivienne E. Reeve,Ian Dixon,Wolfgang Weninger,Timothy P. Cripe,Peter W. Gunning +24 more
TL;DR: In this paper, a novel class of anti-tropomyosin compounds has been developed that preferentially disrupts the actin cytoskeleton of tumor cells, impairing both tumor cell motility and viability.