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Timothy R Sterling
Researcher at Vanderbilt University
Publications - 9
Citations - 152
Timothy R Sterling is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Tuberculosis & Population. The author has an hindex of 4, co-authored 9 publications receiving 56 citations. Previous affiliations of Timothy R Sterling include Vanderbilt University Medical Center.
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Journal ArticleDOI
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Adam Penn-Nicholson,Stanley Kimbung Mbandi,Ethan G. Thompson,Simon C Mendelsohn,Sara Suliman,Sara Suliman,Novel N. Chegou,Stephanus T. Malherbe,Fatoumatta Darboe,Mzwandile Erasmus,Willem A. Hanekom,Nicole Bilek,Michelle Fisher,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann,Jill Winter,Melissa Murphy,Robin Wood,Carl A. Morrow,Ildiko Van Rhijn,D. Branch Moody,Megan Murray,Bruno B. Andrade,Timothy R Sterling,Jayne S. Sutherland,Kogieleum Naidoo,Nesri Padayatchi,Gerhard Walzl,Mark Hatherill,Daniel E. Zak,Thomas J. Scriba,Satvi Clinical,RePORT Brazil Team,Peruvian Household Contacts Cohort Team,Caprisa Impress team +34 more
TL;DR: RISK6 scores correlated with lung immunopathology activity, measured by positron emission tomography, and tracked treatment response, demonstrating utility as treatment response biomarker, while predicting treatment failure prior to treatment initiation.
Journal ArticleDOI
Systematic review of prediction models for pulmonary tuberculosis treatment outcomes in adults.
Lauren S Peetluk,Felipe Ridolfi,Peter F Rebeiro,Dandan Liu,Valeria Cavalcanti Rolla,Timothy R Sterling +5 more
TL;DR: A systematic review and evaluation of prediction models developed to predict tuberculosis (TB) treatment outcomes among adults with pulmonary TB was conducted in this article, where the most common predictors included age, sex, extrapulmonary TB, body mass index, chest X-ray results, previous TB and HIV.
Journal ArticleDOI
Knowledge and stigma of latent tuberculosis infection in Brazil: implications for tuberculosis prevention strategies
Peter F Rebeiro,Mollie J. Cohen,Heather M. Ewing,Marina C. Figueiredo,Lauren S Peetluk,Kleydson B. Andrade,Marshall C. Eakin,Elizabeth J. Zechmeister,Timothy R Sterling +8 more
TL;DR: High proportions of this representative Brazilian population had knowledge of LTBI and were willing to seek treatment for it, however, such knowledge was associated with TB-specific stigma, which must include efforts to decrease TB stigma.
Journal ArticleDOI
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection
Lerato N Ndlovu,Lauren S Peetluk,Sashen Moodley,Shepherd Nhamoyebonde,Abigail Ngoepe,Matilda Mazibuko,Khadija Khan,Farina Karim,Alexander Pym,Fernanda Maruri,Mahomed-Yunus S. Moosa,Yuri F. van der Heijden,Timothy R Sterling,Alasdair Leslie,Alasdair Leslie +14 more
TL;DR: Blood neutrophil metrics could potentially be exploited to develop a simple and rapid test to help determine TB disease severity, monitor drug treatment response, and identify subjects at diagnosis who may respond poorly to treatment.
Posted ContentDOI
RISK6, a universal 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Adam Penn-Nicholson,Stanley Kimbung Mbandi,Ethan G. Thompson,Simon C Mendelsohn,Sara Suliman,Novel N. Chegou,Stephanus T. Malherbe,Fatoumatta Darboe,Mzwandile Erasmus,Willem A. Hanekom,Nicole Bilek,Michelle Fisher,Stefan H. E. Kaufmann,Jill Winter,Melissa Murphy,Robin Wood,Carl A. Morrow,Ildiko Van Rhijn,D. Branch Moody,Megan Murray,Bruno B. Andrade,Timothy R Sterling,Jayne S. Sutherland,Kogieleum Naidoo,Nesri Padayatchi,Gerhard Walzl,Mark Hatherill,Daniel E. Zak,Thomas J. Scriba +28 more
TL;DR: RISK6 scores correlated with lung immunopathology activity, measured by positron emission tomography, and tracked treatment response, demonstrating utility as treatment response biomarker, while predicting treatment failure prior to treatment initiation.