Jayne S. Sutherland

TL;DR: The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.

TL;DR: It is demonstrated that androgen ablation results in the complete regeneration of the aged male mouse thymus, restoration of peripheral T cell phenotype and function and enhancedThymus regeneration following bone marrow transplantation.

TL;DR: Unexpected interactions appear to exist between the timing of hormonal therapy and radiation field size for this patient population and additional studies are warranted to determine whether the failure to demonstrate an advantage for NHT + WPRT compared with PORT + AHT is chance or, more likely, reflects a previously unrecognized biologic phenomenon.

TL;DR: Despite a robust response to TB antigens in active TB disease, changes in the pattern of cytokine production between TB infection and disease clearly contribute to disease progression.

TL;DR: Although castration impacts globally across thymocyte development in middle-aged mice, the regenerative effects are initiated in the immature triple-negative compartment and early T lineage progenitors (ETP), and it is demonstrated castration enhances intrathymic proliferation and promotes differentiation through the triple- negative program.