Timothy S. Wallis

TL;DR: It is found that the flhD mutant was more virulent than its parent in the mouse and displayed slightly faster net growth between 4 and 24 h of infection in mouse macrophages, and the latter is more predictive of findings in the calf enterocolitis model.

TL;DR: The first comprehensive survey for EHEC factors mediating colonization of the bovine intestines by using signature-tagged transposon mutagenesis is reported, and it is demonstrated that a mutant harbouring a deletion of the putative major fimbrial subunit gene is rapidly out-competed by the parent strain in co-infection studies.

TL;DR: It is shown that SopE2 is an important invasion-associated effector in Salmonella pathogenicity and highly homologous to SopE, a protein encoded by a gene within a temperate bacteriophage and present in only some pathogenic strains.

TL;DR: Salmonella dublin was found to be significantly less invasive in cultured cells than S. typhimurium, but this difference was not observed in bovine intestines, and the invH mutants exhibited a significant reduction in invasion in both cultured cells and bovines.

TL;DR: There was, however, no observable difference compared with wild type in the interaction of sodC mutants with porcine pleural, mouse peritoneal or J774 macrophages in vitro, perhaps reflecting the hierarchical capacity of different macrophage lines to kill Salmonella, the most efficient overwhelming the proposed protective effect of periplasmic SOD.