P
Paul R. Langford
Researcher at Imperial College London
Publications - 215
Citations - 6500
Paul R. Langford is an academic researcher from Imperial College London. The author has contributed to research in topics: Actinobacillus pleuropneumoniae & Gene. The author has an hindex of 41, co-authored 199 publications receiving 5627 citations. Previous affiliations of Paul R. Langford include Aston University & University of Nottingham.
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Journal ArticleDOI
Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection.
Janine T. Bossé,Håkan Janson,Brian J. Sheehan,Amanda Beddek,Andrew N. Rycroft,J. Simon Kroll,Paul R. Langford +6 more
TL;DR: This review considers how adhesins, iron-acquisition factors, capsule and lipopolysaccharide, RTX cytotoxins and other potential future vaccine components contribute to colonisation, to avoidance of host clearance mechanisms and to damage of host tissues.
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Diagnosis of childhood tuberculosis and host RNA expression in Africa.
Suzanne T. Anderson,Myrsini Kaforou,Andrew Brent,Victoria J. Wright,Claire M. Banwell,George Chagaluka,Amelia C. Crampin,Hazel M. Dockrell,Neil French,Melissa Hamilton,Martin L. Hibberd,Florian Kern,Paul R. Langford,Ling Ling,Rachel Mlotha,Tom H. M. Ottenhoff,Sandy Pienaar,Vashini Pillay,J. Anthony G. Scott,Hemed Twahir,Robert J. Wilkinson,Lachlan J. M. Coin,Robert S. Heyderman,Michael Levin,Brian Eley +24 more
TL;DR: RNA expression signatures provided data that helped distinguish tuberculosis from other diseases in African children with and those without HIV infection.
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Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study
Myrsini Kaforou,Victoria J. Wright,Tolu Oni,Tolu Oni,Neil French,Neil French,Suzanne T. Anderson,Suzanne T. Anderson,Nonzwakazi Bangani,Claire M. Banwell,Claire M. Banwell,Andrew Brent,Andrew Brent,Amelia C. Crampin,Hazel M. Dockrell,Brian Eley,Robert S. Heyderman,Robert S. Heyderman,Martin L. Hibberd,Florian Kern,Paul R. Langford,Ling Ling,Marc Mendelson,Tom H. M. Ottenhoff,Femia Zgambo,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Lachlan J. M. Coin,Lachlan J. M. Coin,Michael Levin +30 more
TL;DR: Using a microarray-based approach, Michael Levin and colleagues develop a disease risk score to distinguish active from latent tuberculosis, as well as tuberculosis from other diseases, using whole blood samples.
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Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ
Beate Kampmann,Cheryl Hemingway,Alick C Stephens,Robert N. Davidson,Anna Goodsall,Suzanne T. Anderson,Mark P. Nicol,Elisabeth H. Schölvinck,David A. Relman,Simon J. Waddell,Paul R. Langford,Brian J. Sheehan,Lynn Semple,Katalin A. Wilkinson,Robert J. Wilkinson,Stanley R. Ress,Martin L. Hibberd,Michael Levin +17 more
TL;DR: It is postulated that acquired defects in macrophage activation by IFN-gamma may cause a similar immunological phenotype and thus explain the occurrence of disseminated intracellular infections in some patients without identifiable immune deficiency.
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Dysbiosis Anticipating Necrotizing Enterocolitis in Very Premature Infants
Kathleen Sim,Alexander G. Shaw,Paul Randell,Michael J. Cox,Zoë E. McClure,Ming-Shi Li,Munther Haddad,Paul R. Langford,William O.C.M. Cookson,Miriam F. Moffatt,J. Simon Kroll +10 more
TL;DR: Using 16S rRNA gene sequencing and targeted culture, microbiota in fecal samples from infants with necrotizing enterocolitis and controls were compared and two significant signatures were associated with NEC.