Glenn Longenecker

TL;DR: Cdk5(-/-) mice exhibit unique lesions in the central nervous system associated with perinatal mortality and also suggest that Cdk5 may play critical roles in neuronal cytoskeleton structure and organization.

TL;DR: This is the first report in which deficiency of a non-collagenous ECM protein leads to a skeletal phenotype that is marked by low bone mass that becomes more obvious with age and may serve as an animal model to study the role of ECM proteins in osteoporosis.

TL;DR: Targeted gene expression has been achieved in the liver, albeit at low levels, suggesting that adenovirus vectors may be a useful means for in vivo gene therapy in liver disorders.

TL;DR: The disruption of the amelogenin locus is disrupted to generate amelgenin null mice, which display distinctly abnormal teeth as early as 2 weeks of age with chalky-white discoloration, and reveals that the amELogenins are apparently not required for initiation of mineral crystal formation but rather for the organization of crystal pattern and regulation of enamel thickness.

TL;DR: It is proposed that SLPI is a pivotal endogenous factor necessary for optimal wound healing in mice null for the gene encoding SLPI, which show impaired cutaneous wound healing with increased inflammation and elastase activity.