T
Tina Solvik
Researcher at University of California, San Francisco
Publications - 6
Citations - 332
Tina Solvik is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Secretion & Autophagy. The author has an hindex of 3, co-authored 5 publications receiving 141 citations. Previous affiliations of Tina Solvik include University of California, Berkeley.
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Journal ArticleDOI
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
Andrew M. Leidal,Hector H. Huang,Timothy Marsh,Tina Solvik,Dachuan Zhang,Jordan Ye,FuiBoon Kai,Juliet Goldsmith,Jennifer Y. Liu,Yu-Hsin Huang,Teresa Monkkonen,Ariadne Vlahakis,Eric J. Huang,Hani Goodarzi,Li Yu,Arun P. Wiita,Jayanta Debnath +16 more
TL;DR: It is shown that the LC3-conjugation pathway, which is part of the autophagy machinery, controls extracellular vesicle cargo loading and secretion of RNA-binding proteins.
Journal ArticleDOI
Secretory autophagy maintains proteostasis upon lysosome inhibition
Tina Solvik,Tan A. Nguyen,Yu-Hsiu Tony Lin,Timothy Marsh,Eric J. Huang,Arun P. Wiita,Jayanta Debnath,Andrew M. Leidal +7 more
TL;DR: Secretory autophagy via EVPs functions as an alternate route to clear sequestered material and maintain proteostasis during endolysosomal dysfunction or impaired autophagosome maturation.
Journal ArticleDOI
Bacterial alginate regulators and phage homologs repress CRISPR-Cas immunity.
Adair L. Borges,Bardo Castro,Sutharsan Govindarajan,Sutharsan Govindarajan,Tina Solvik,Veronica Escalante,Joseph Bondy-Denomy,Joseph Bondy-Denomy +7 more
TL;DR: The identification of the KinB–AlgB two-component system, known to modulate alginate biosynthesis, together with downstream proteins that repress the Type I-F CRISPR–Cas system in Pseudomonas aeruginosa, elucidates how bacteria control the expression of nucleolytic host defence systems to minimize the potential risks of self-targeting.
Posted ContentDOI
Autophagy cargo receptors are secreted via extracellular vesicles and particles in response to endolysosomal inhibition or impaired autophagosome maturation
Tina Solvik,Tan A. Nguyen,Yu-Hsiu Tony Lin,Timothy Marsh,Eric J. Huang,Arun P. Wiita,Jayanta Debnath,Andrew M. Leidal +7 more
TL;DR: In this article, a secretory autophagy pathway upregulated in response to endolysosomal inhibition that mediates the EVP-associated extracellular release of autophagic cargo receptors, including p62/SQSTM1.
Journal ArticleDOI
At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication
Tina Solvik,Jayanta Debnath +1 more
TL;DR: An unbiased RNA interference screen of the ATG proteome is conducted to reveal numerous noncanonical roles for ATG proteins during viral infection.