T
Tiphanie P. Vogel
Researcher at Baylor College of Medicine
Publications - 69
Citations - 2278
Tiphanie P. Vogel is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 20, co-authored 46 publications receiving 1393 citations. Previous affiliations of Tiphanie P. Vogel include Washington University in St. Louis & Boston Children's Hospital.
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Journal ArticleDOI
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Joshua D. Milner,Tiphanie P. Vogel,Lisa R. Forbes,Chi Ma,Asbjørg Stray-Pedersen,Julie E. Niemela,Jonathan J. Lyons,Karin R. Engelhardt,Yu Zhang,Nermina Topcagic,Elisha D.O. Roberson,Helen F. Matthews,James W. Verbsky,Trivikram Dasu,Alexander Vargas-Hernández,Nidhy Varghese,Kenneth L. McClain,Lina Karam,Karen Nahmod,George Makedonas,Emily M. Mace,Hanne Sørmo Sorte,Gøri Perminow,V. Koneti Rao,Michael P. O'Connell,Susan Price,Helen C. Su,Morgan Butrick,Joshua J McElwee,Jason D. Hughes,Joseph D. P. Willet,David J. Swan,Yaobo Xu,Mauro Santibanez-Koref,Voytek Slowik,Darrell L. Dinwiddie,Darrell L. Dinwiddie,Christina E. Ciaccio,Carol J Saunders,Carol J Saunders,Seth Septer,Stephen F. Kingsmore,Stephen F. Kingsmore,Andrew J. White,Andrew J. Cant,Andrew J. Cant,Sophie Hambleton,Sophie Hambleton,Megan A. Cooper +48 more
TL;DR: There is a broad range of autoimmunity caused by germline STAT3 gain-of-function mutations, and that hematologic autoIMmunity is a major component of this newly described disorder.
Journal ArticleDOI
Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production
TL;DR: It is demonstrated that metabolism provides an essential second signal for induction of IFN-γ production by activating NK cell receptors that can be reversed with prolonged high-dose IL-15 treatment.
Journal ArticleDOI
Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.
Lisa R. Forbes,Tiphanie P. Vogel,Megan A. Cooper,Johana Castro-Wagner,Edith Schussler,Katja G. Weinacht,Ashley Plant,Helen C. Su,Eric J. Allenspach,Mary Slatter,Mario Abinun,Desa Lilic,Charlotte Cunningham-Rundles,Olive S. Eckstein,Peter Olbrich,R. Paul Guillerman,Niraj C. Patel,Yesim Y. Demirdag,Christa S. Zerbe,Alexandra F. Freeman,Steven M. Holland,Paul Szabolcs,Andrew R. Gennery,Troy R. Torgerson,Joshua D. Milner,Jennifer W. Leiding,Jennifer W. Leiding +26 more
TL;DR: Jinibs have been used to treat the severe immune-dysregulation in patients with either STAT1 GOF or STAT3 GOF mutations.
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Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data.
Tiphanie P. Vogel,Karina A. Top,Christos Karatzios,David C. Hilmers,Lorena I. Tapia,Pamela Moceri,Lisa Giovannini-Chami,Nicholas Wood,Rebecca E. Chandler,Nicola P. Klein,Elizabeth P. Schlaudecker,M. Cecilia Poli,Eyal Muscal,Flor M. Munoz +13 more
TL;DR: The Brighton Collaboration case definition of Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A) was developed by topic experts in the context of active development of vaccines for SARS-CoV-2 as discussed by the authors.
Journal ArticleDOI
The Ying and Yang of STAT3 in Human Disease
TL;DR: This review summarizes what is known about the role of STAT3 in human disease and identifies germline, heterozygous mutations in STAT3 that confer a gain-of-function that result in early-onset, multi-organ autoimmunity.