Amelie Lier

TL;DR: This work shows in mice that DNA damage is a direct consequence of inducing HSCs to exit their homeostatic quiescent state in response to conditions that model physiological stress, such as infection or chronic blood loss, and provides a mechanistic explanation for the universal accumulation of DNA damage in H SCs during ageing and the accelerated failure of the haematopoietic system in Fanconi anaemia patients.

TL;DR: An unexpectedly dynamic pattern of transcript isoform regulation is found, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells is found.

TL;DR: This patient-derived xenograft model provides functional and molecular evidence that MDS is a complex disease that involves both the hematopoietic and stromal compartments.

TL;DR: An overview of the clinical implications of TMB testing is provided and key parameters including pre-analysis, analysis and post-analytical steps that influence and shape TMB approximation by panel sequencing are highlighted.

TL;DR: MASTER (Molecularly Aided Stratification for Tumor Eradication Research), a clinically applicable platform for prospective, biology‐driven stratification of younger adults with advanced‐stage cancer across all histologies and patients with rare tumors is described.