T
Todd A. Hardy
Researcher at University of Sydney
Publications - 74
Citations - 2567
Todd A. Hardy is an academic researcher from University of Sydney. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 23, co-authored 58 publications receiving 1979 citations. Previous affiliations of Todd A. Hardy include Royal Prince Alfred Hospital & University of Colorado Denver.
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Journal ArticleDOI
Diagnosis of multiple sclerosis: progress and challenges
TL;DR: The progress and challenges in the diagnosis of multiple sclerosis with reference to diagnostic criteria, important differential diagnoses, controversies and uncertainties, and future prospects are explored.
Journal ArticleDOI
C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
Anna Richards,Arn M. J. M. van den Maagdenberg,Joanna C. Jen,David J. Kavanagh,Paula Bertram,Dirk Spitzer,M. Kathryn Liszewski,Maria Louise Barilla-Labarca,Gisela M. Terwindt,Yumi Kasai,Michael D. McLellan,Mark Gilbert Grand,Kaate R J Vanmolkot,Boukje de Vries,Jijun Wan,Michael J. Kane,Hafsa Mamsa,Ruth Schäfer,Anine H. Stam,Joost Haan,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Caroline W. Storimans,Mary J. van Schooneveld,J. A. Oosterhuis,Andreas Gschwendter,Martin Dichgans,Katya E. Kotschet,Suzanne Hodgkinson,Todd A. Hardy,Martin B. Delatycki,Rula A. Hajj-Ali,Parul H. Kothari,Stanley F. Nelson,Rune R. Frants,Robert W. Baloh,Michel D. Ferrari,John P. Atkinson +37 more
TL;DR: Heterozygous C-terminal frameshift mutations in TREX1 retain exonuclease activity but lose normal perinuclear localization, which has implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias.
Journal ArticleDOI
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
Sudarshini Ramanathan,Kristina Prelog,Elizabeth H Barnes,Esther M Tantsis,Stephen W. Reddel,Andrew P.D. Henderson,Steve Vucic,Mark P. Gorman,Leslie Benson,Gulay Alper,Catherine J. Riney,Michael Barnett,John Parratt,Todd A. Hardy,Richard J. Leventer,Vera Merheb,Margherita Nosadini,Victor S.C. Fung,Fabienne Brilot,Russell C. Dale +19 more
TL;DR: The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS.
Journal ArticleDOI
Tumefactive demyelination: an approach to diagnosis and management
Todd A. Hardy,Jeremy Chataway +1 more
TL;DR: It is argued that disease modifying therapy should be considered for acute tumefactive demyelinating lesions only once criteria of dissemination in time and space are fulfilled and the diagnosis of multiple sclerosis is confirmed.
Journal ArticleDOI
Atypical inflammatory demyelinating syndromes of the CNS.
Todd A. Hardy,Stephen W. Reddel,Michael Barnett,Michael Barnett,Jacqueline Palace,Claudia F. Lucchinetti,Brian G. Weinshenker +6 more
TL;DR: Advances in MRI, pathology, and immunobiology are needed to increase understanding of these syndromes, including the extent to which some of them represent distinct entities, and to assist with improvements in their diagnosis and management.