T
Todd R. Graham
Researcher at Vanderbilt University
Publications - 142
Citations - 8946
Todd R. Graham is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Golgi apparatus & Flippase. The author has an hindex of 51, co-authored 136 publications receiving 8129 citations. Previous affiliations of Todd R. Graham include University of Portland & University of Leeds.
Papers
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Journal ArticleDOI
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.
Ainslie B. Parsons,Andres Lopez,Inmar E. Givoni,David E. Williams,Christopher A. Gray,Justin Porter,Gordon Chua,Richelle Sopko,Renee L. Brost,Cheuk-Hei Ho,Jiyi Wang,Troy Ketela,Charles Brenner,Julie A. Brill,G. Esteban Fernandez,Todd C. Lorenz,Gregory S. Payne,Satoru Ishihara,Yoshikazu Ohya,Brenda J. Andrews,Timothy P. Hughes,Brendan J. Frey,Todd R. Graham,Raymond J. Andersen,Charles Boone +24 more
TL;DR: A compendium of "chemical-genetic interaction" profiles by testing the collection of viable yeast haploid deletion mutants for hypersensitivity to 82 compounds and natural product extracts is generated, found to disrupt calcium homeostasis and phosphatidylserine was recognized as a target for papuamide B, a cytotoxic lipopeptide with anti-HIV activity.
Journal ArticleDOI
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.
Todd R. Graham,Scott D. Emr +1 more
TL;DR: The sec18 and sec23 secretory mutants of Saccharomyces cerevisiae have been shown to exhibit temperature-conditional defects in protein transport from the ER to the Golgi complex, and at least three functionally distinct Golgi compartments in yeast are defined.
Journal ArticleDOI
SOCIAL MEDIA AS BEAT: Tweets as a news source during the 2010 British and Dutch elections
Marcel Broersma,Todd R. Graham +1 more
TL;DR: This article investigated the use of Twitter as a source for newspaper coverage of the 2010 British and Dutch elections and found that almost a quarter of the British and nearly half of the Dutch candidates shared their thoughts, visions, and experiences on Twitter.
Journal ArticleDOI
Between broadcasting political messages and interacting with voters
TL;DR: In this article, the authors investigate how candidates are using Twitter during an election campaign and create a typology of the various ways in which candidates behaved on Twitter, focusing on four aspects of tweets: type, interaction, function and topic.
Journal ArticleDOI
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.
Cheuk Hei Ho,Leslie Magtanong,Sarah L. Barker,David Gresham,Shinichi Nishimura,Paramasivam Natarajan,Judice L. Y. Koh,Justin Porter,Christopher A. Gray,Raymond J. Andersen,Guri Giaever,Corey Nislow,Brenda J. Andrews,David Botstein,Todd R. Graham,Minoru Yoshida,Charles Boone +16 more
TL;DR: A yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds is presented, and a new class of sterol-binding compounds is discovered.