T
Tohru Tanaka
Researcher at Tokyo Institute of Technology
Publications - 116
Citations - 2064
Tohru Tanaka is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Ferrous citrate & Protoporphyrin IX. The author has an hindex of 20, co-authored 114 publications receiving 1621 citations. Previous affiliations of Tohru Tanaka include Tokyo Medical University.
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Journal ArticleDOI
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy
Masahiro Ishizuka,Fuminori Abe,Yuki Sano,Kiwamu Takahashi,Katsushi Inoue,Motowo Nakajima,Takeo Kohda,Naoki Komatsu,Shun-ichiro Ogura,Tohru Tanaka +9 more
TL;DR: The biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed.
Journal ArticleDOI
New Physiological Effects of 5-Aminolevulinic Acid in Plants: The Increase of Photosynthesis, Chlorophyll Content, and Plant Growth
TL;DR: It is suggested that ALA have a variety of plant physiological effects on chlorophyll synthesis, photosynthesis, and plant growth, and ALA acts as a growth regulator in plants at low concentrations.
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Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro
Yuichiro Hagiya,Yoshio Endo,Yutaka Yonemura,Kiwamu Takahashi,Masahiro Ishizuka,Fuminori Abe,Tohru Tanaka,Ichiro Okura,Motowo Nakajima,Toshihisa Ishikawa,Shun-ichiro Ogura +10 more
TL;DR: PEPT1 and ABCG2 are key players in regulating intracellular PpIX levels and determining the efficacy of ALA-based photocytotoxicity against gastric cancer cells in vitro.
Journal ArticleDOI
Improvement of cold resistance in rice seedlings by 5-aminolevulinic acid
TL;DR: Results are the first evidence that ALA has protective effects against cold stress in rice seedlings and Abscisic acid (ABA) and brassinolide (BR) also increased the cold resistance in the bioassay system.
Journal ArticleDOI
Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
Yuichiro Hagiya,Hideo Fukuhara,Kentaro Matsumoto,Yoshio Endo,Motowo Nakajima,Tohru Tanaka,Ichiro Okura,Atsushi Kurabayashi,Mutsuo Furihata,Keiji Inoue,Taro Shuin,Shun-ichiro Ogura +11 more
TL;DR: The induction of PEPT1 gene and the suppression of ABCG2 gene expression are among the key molecular mechanisms underlying tumor-specific PpIX accumulation after the administration of ALA in bladder cancer.