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Masahiro Ishizuka
Researcher at Cosmo Oil Company
Publications - 80
Citations - 1032
Masahiro Ishizuka is an academic researcher from Cosmo Oil Company. The author has contributed to research in topics: Protoporphyrin IX & Photodynamic therapy. The author has an hindex of 15, co-authored 72 publications receiving 828 citations. Previous affiliations of Masahiro Ishizuka include Kōchi University.
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Journal ArticleDOI
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy
Masahiro Ishizuka,Fuminori Abe,Yuki Sano,Kiwamu Takahashi,Katsushi Inoue,Motowo Nakajima,Takeo Kohda,Naoki Komatsu,Shun-ichiro Ogura,Tohru Tanaka +9 more
TL;DR: The biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed.
Journal ArticleDOI
Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro
Yuichiro Hagiya,Yoshio Endo,Yutaka Yonemura,Kiwamu Takahashi,Masahiro Ishizuka,Fuminori Abe,Tohru Tanaka,Ichiro Okura,Motowo Nakajima,Toshihisa Ishikawa,Shun-ichiro Ogura +10 more
TL;DR: PEPT1 and ABCG2 are key players in regulating intracellular PpIX levels and determining the efficacy of ALA-based photocytotoxicity against gastric cancer cells in vitro.
The Effect of 5-Aminolevulinic Acid on Cytochrome c Oxidase Activity
Yuta Sugiyama,Yuichiro Hagiya,Tetsuya Hayashi,Kyoko Tsuchiya,Masahiro Ishizuka,Ichiro Okura,Shun-ichiro Ogura +6 more
TL;DR: In this article, 5-aminolevulinic acid (ALA) was administered to mice for 10 consecutive days to increase COX protein levels and activity in liver after ALA injection.
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5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1.
Yoshiaki Nishio,Masayuki Fujino,Mingyi Zhao,Takuya Ishii,Masahiro Ishizuka,Hidenori Ito,Kiwamu Takahashi,Fuminori Abe,Motowo Nakajima,Tohru Tanaka,Shigeru Taketani,Yukitoshi Nagahara,Xiao-Kang Li +12 more
TL;DR: Exposure of 5-ALA/SFC to RAW264 cells enhances the HO-1 expression via MAPK activation along with the negative regulation of Bach1, and increased heme indicated that the inactivation of Bach 1 by heme supports the upregulation of HO- 1 expression.
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Extraction and cleanup methods of dioxins in house dust from two cities in Japan using accelerated solvent extraction and a disposable multi-layer silica-gel cartridge.
Koichi Saito,Mikiko Takekuma,Masahiko Ogawa,Susumu Kobayashi,Yukio Sugawara,Masahiro Ishizuka,Hiroyuki Nakazawa,Yasuhiko Matsuki +7 more
TL;DR: It was found that the WHO-TEQ levels of dioxins extracted from the house dust obtained by both a conventional soxhlet extraction and the ASE were almost equal, when the data obtaining by both methods were compared.